Spongiacidin C

Spongiacidin C

SCHEMBL22480163

O=C1NC(=O)/C(=C2\CCNC(=O)c3[nH]ccc32)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKD3 O94806 3/20 1.00
PRKCG P05129 3/20 1.00
PRKCB P05771 3/20 1.00
PRKCA P17252 3/20 1.00
PRKCH P24723 3/20 1.00
PRKCI P41743 3/20 1.00
PRKCE Q02156 3/20 1.00
PRKCQ Q04759 3/20 1.00
PRKCZ Q05513 3/20 1.00
PRKCD Q05655 3/20 1.00
PRKD1 Q15139 3/20 1.00
USP7 Q93009 1/20 1.00
USP21 Q9UK80 1/20 1.00
CDK5 Q00535 6/20 0.60
CDK5R1 Q15078 6/20 0.60
CCNB2 O95067 4/20 0.60
CDK1 P06493 4/20 0.60
CCNB1 P14635 4/20 0.60
CCNB3 Q8WWL7 4/20 0.60
CSNK1A1 P48729 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13639132 0.85 PRKD3 (0.74) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL13222150 0.85 PRKD3 (0.74) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL13222116 0.76 MAP2K1 (0.62) PRKD3PRKCGPRKCBPRKCAPRKCH
Debromohymenialdisine SCHEMBL3578000 0.76 CDK5 (0.70) PRKD3PRKCGPRKCBPRKCAPRKCH
Debromohymenialdisine SCHEMBL3577997 0.76 CDK5 (0.70) PRKD3PRKCGPRKCBPRKCAPRKCH
Debromohymenialdisine SCHEMBL4303192 0.76 CDK5 (0.70) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL17166865 0.75 CDK5 (0.71) PRKD3PRKCGPRKCBPRKCAPRKCH
Spongiacidin D SCHEMBL15426068 0.75 CDK5 (1.00) PRKD3PRKCGPRKCBPRKCAPRKCH
Aldisin SCHEMBL7844916 0.73 MAP2K1 (1.00) PRKD3PRKCGPRKCBPRKCAPRKCH
Debromohymenialdisine SCHEMBL30092237 0.71 CDK5 (1.00) PRKD3PRKCGPRKCBPRKCAPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3515559-B1 COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS DANA FARBER CANCER INST INC (US) 2025-05-21 EP disclosed
WO-2020196453-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR IL-33-RELATED DISEASES 国立大学法人千葉大学 2020-10-01 WO disclosed