Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 3/20 | 0.74 |
| ▸ | PRKCG | P05129 | 3/20 | 0.74 |
| ▸ | PRKCB | P05771 | 3/20 | 0.74 |
| ▸ | PRKCA | P17252 | 3/20 | 0.74 |
| ▸ | PRKCH | P24723 | 3/20 | 0.74 |
| ▸ | PRKCI | P41743 | 3/20 | 0.74 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.74 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.74 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.74 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.74 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.74 |
| ▸ | USP7 | Q93009 | 1/20 | 0.74 |
| ▸ | USP21 | Q9UK80 | 1/20 | 0.74 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222150 | 1.00 | PRKD3 (0.74) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Spongiacidin C SCHEMBL22480163 | 0.85 | PRKD3 (1.00) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL13222116 | 0.74 | MAP2K1 (0.62) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Debromohymenialdisine SCHEMBL3577997 | 0.74 | CDK5 (0.70) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Debromohymenialdisine SCHEMBL4303192 | 0.74 | CDK5 (0.70) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Debromohymenialdisine SCHEMBL3578000 | 0.74 | CDK5 (0.70) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Aldisin SCHEMBL7844916 | 0.71 | MAP2K1 (1.00) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Debromohymenialdisine SCHEMBL29358509 | 0.69 | CDK5 (1.00) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Debromohymenialdisine SCHEMBL30092237 | 0.69 | CDK5 (1.00) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL13222124 | 0.69 | PRKD3 (0.36) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304408-B2 | Wnt signaling inhibitors, and methods for making and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-06 | — | — | US | disclosed |
| US-8304408-B2 | Wnt signaling inhibitors, and methods for making and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100203113-A1 | WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100203113-A1 | WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100203113-A1 | WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM | WNT1, DACH1, WNT3A | PRKD3 913/4885PRKCG 1043/4885PRKCB 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.