Aldisin

Aldisin

SCHEMBL7844916

O=C1CCNC(=O)c2[nH]ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 3/20 1.00
PRKD3 O94806 1/20 0.57
PRKCG P05129 1/20 0.57
PRKCB P05771 1/20 0.57
PRKCA P17252 1/20 0.57
PRKCH P24723 1/20 0.57
PRKCI P41743 1/20 0.57
PRKCE Q02156 1/20 0.57
PRKCQ Q04759 1/20 0.57
PRKCZ Q05513 1/20 0.57
PRKCD Q05655 1/20 0.57
PRKD1 Q15139 1/20 0.57
USP7 Q93009 1/20 0.57
USP21 Q9UK80 1/20 0.57
RAF1 P04049 2/20 0.51
MAPK1 P28482 2/20 0.51
CHEK1 O14757 1/20 0.51
CCNB2 O95067 1/20 0.51
CHEK2 O96017 1/20 0.51
CDK1 P06493 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6891945 0.84 MAP2K1 (0.72) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL13222116 0.77 MAP2K1 (0.62) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL21305078 0.76 MAP2K1 (0.61) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL15468004 0.75 MAP2K1 (0.60) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL980230 0.73 MAP2K1 (0.58) MAP2K1PRKD3PRKCGPRKCBPRKCA
Spongiacidin C SCHEMBL22480163 0.73 PRKD3 (1.00) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL13639132 0.71 PRKD3 (0.74) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL13222150 0.71 PRKD3 (0.74) MAP2K1PRKD3PRKCGPRKCBPRKCA
SCHEMBL3296103 0.71 PARP11 (0.64) MAP2K1RAF1MAPK1PARP10PARP1
SCHEMBL22313400 0.69 PARP11 (0.62) MAP2K1RAF1MAPK1PARP10PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118766933-A Application of Aldrisin compound in preparation of medicines for treating inflammatory bowel disease 上海交通大学医学院附属仁济医院 2024-10-15 CN claimed
WO-2024063670-A1 CYCLIN-DEPENDENT KINASE 7 INHIBITORS Акционерное общество "БИОКАД" 2024-03-28 WO claimed
CN-115246834-B Aldrisin derivative, preparation thereof and application thereof in preventing and treating plant viruses, killing insects and killing bacteria 南开大学 2023-10-13 CN claimed
CN-115246836-B Aldrisin derivative containing acylhydrazone structure and preparation and application thereof 南开大学 2023-10-13 CN claimed
CN-115246835-B Aldrisin derivative containing hydrazone structure and preparation and application thereof 南开大学 2023-05-30 CN claimed
CN-111132666-B Composition for delivering physiologically active ingredients to blood vessels 雷莫内克斯生物制药有限公司 2022-11-04 CN claimed
CN-115246835-A Hydrazone structure-containing Aldisin derivative and preparation and application thereof 南开大学 2022-10-28 CN claimed
CN-115246834-A Aldisin derivative, preparation thereof and application thereof in preventing and treating plant viruses, killing insects and killing bacteria 南开大学 2022-10-28 CN claimed
CN-115246836-A Aldisin derivative containing acylhydrazone structure and preparation and application thereof 南开大学 2022-10-28 CN claimed
CN-115245170-A Application of Aldisin and alkaloid derivatives thereof in preventing and treating plant viruses, killing insects and killing bacteria 南开大学 2022-10-28 CN claimed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
CN-118766933-B Application of Aldrisin compound in preparation of medicines for treating inflammatory bowel disease 上海交通大学医学院附属仁济医院 2025-11-18 CN disclosed
CN-119365471-A Novel thiol reducing agents, methods and uses thereof 苏州佰睿壹生物技术有限公司 2025-01-24 CN disclosed
CN-119325483-A Preparation method of antibody with site-specific modification 苏州佰睿壹生物技术有限公司 2025-01-17 CN disclosed
CN-115245170-B Application of Aldisin and alkaloid derivatives thereof in preventing and treating plant viruses, killing insects and killing bacteria 南开大学 2024-10-22 CN disclosed
EP-0441349-B1 Pyrroloazepine derivatives SUNTORY LTD (JP) 1996-01-03 EP disclosed
US-5416082-A Antiserotonine agents SUNTORY LIMITED (JP) 1995-05-16 US disclosed
US-5391731-A Useful therapeutics for circulatory diseases SUNTORY LIMITED (JP) 1995-02-21 US disclosed
US-5206239-A Cardiovascular disorders SUNTORY LIMITED (JP) 1993-04-27 US disclosed
EP-0441349-A1 Pyrroloazepine derivatives SUNTORY LIMITED (JP) 1991-08-14 EP disclosed