Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | DTYMK | P23919 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12357647 | 0.92 | GPR119 (0.46) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL2250127 | 0.89 | ALDH1A1 (0.47) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL8103415 | 0.86 | OPRL1 (0.53) | GPR119OPRM1STSKDM4EPKM | |
| SCHEMBL3764320 | 0.85 | PIK3CA (0.51) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL2251051 | 0.85 | GPR119 (0.46) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL29712771 | 0.82 | GPR119 (0.47) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL27100998 | 0.82 | GPR119 (0.47) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL12357645 | 0.81 | ALDH1A1 (0.49) | GPR119DTYMKDDB1CRBNOPRM1 | |
| SCHEMBL2251115 | 0.80 | TP53 (0.42) | OPRM1OPRD1PRKDCPOLBKDM4E | |
| SCHEMBL26671857 | 0.78 | GPR119 (0.49) | GPR119DTYMKDDB1CRBNOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190336-A1 | AZABENZIMIDAZOLONES | CARA THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2010045276-A2 | AZABENZIMIDAZOLONES | CARA THERAPEUTICS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190336-A1 | AZABENZIMIDAZOLONES | PTGER1, PTGDR, PTGER2 | GPR119 569/4885DTYMK 2455/4885DDB1 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.