Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27194855 | 0.88 | C5AR1 (0.59) | GPR119CACNA1GCACNA1HSTS | |
| SCHEMBL8111309 | 0.88 | ALDH1A1 (0.57) | OPRL1OPRM1KDM4E | |
| SCHEMBL8063089 | 0.87 | OPRM1 (0.50) | OPRL1OPRM1GPR119CACNA1GCACNA1H | |
| SCHEMBL7596262 | 0.86 | OPRM1 (0.49) | OPRL1OPRM1GPR119CACNA1GCACNA1H | |
| SCHEMBL14518248 | 0.86 | OPRL1 (0.47) | OPRL1OPRM1GPR119CACNA1GCACNA1H | |
| SCHEMBL12357647 | 0.86 | GPR119 (0.46) | OPRM1GPR119STSKDM4EPKM | |
| SCHEMBL2248124 | 0.86 | GPR119 (0.46) | OPRM1GPR119STSKDM4EPKM | |
| SCHEMBL3098947 | 0.85 | CYP2D6 (0.57) | OPRL1OPRM1GPR119CACNA1GCACNA1H | |
| SCHEMBL4717854 | 0.85 | OPRL1 (0.47) | OPRL1OPRM1GPR119CACNA1GCACNA1H | |
| SCHEMBL24709345 | 0.85 | CACNA1G (0.66) | OPRL1OPRM1GPR119CACNA1GCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716661-B1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS INC (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5817756-A | USING A MODIFIED DI- OR TRI-PEPTIDES | SCIOS INC. (US) | 1998-10-06 | — | — | US | disclosed |
| WO-1995007294-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1995-03-16 | — | — | WO | disclosed |