Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22482705 | 0.80 | POU2F2 (0.38) | — | |
| SCHEMBL4318016 | 0.79 | P2RX7 (0.41) | ALDH1A1L3MBTL1MAPTHPGD | |
| SCHEMBL20014851 | 0.78 | ALKBH1 (0.38) | L3MBTL1POLBHPGD | |
| SCHEMBL5124464 | 0.76 | GRM5 (0.41) | ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL20015193 | 0.73 | ALKBH1 (0.38) | ALDH1A1KDM4EHPGD | |
| SCHEMBL5531193 | 0.73 | LMNA (0.49) | ALDH1A1L3MBTL1POLBMAPTTDP1 | |
| SCHEMBL19158637 | 0.73 | HRH3 (0.36) | ALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL19158183 | 0.71 | KDM4E (0.38) | ALDH1A1KDM4E | |
| SCHEMBL4319305 | 0.70 | POLB (0.43) | ALDH1A1L3MBTL1KDM4EPOLBGAA | |
| SCHEMBL10188463 | 0.70 | GLRA1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4122537-A1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE | Gilead Sciences, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| EP-3938047-B1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE | GILEAD SCIENCES INC (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2020197991-A1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE | GILEAD SCIENCES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |