Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24472873 | 0.86 | HDAC6 (0.60) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL20847480 | 0.84 | HDAC6 (0.43) | HDAC6HDAC8HDAC11HDAC3KCNA5 | |
| SCHEMBL24473206 | 0.82 | HDAC6 (0.48) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL24472776 | 0.78 | HDAC6 (0.59) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL22482914 | 0.76 | HDAC6 (0.37) | HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL24473211 | 0.75 | HDAC6 (0.54) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL20847775 | 0.73 | KMT2A (0.44) | HDAC6HDAC8HDAC11HDAC3NSD2 | |
| SCHEMBL20847600 | 0.71 | HDAC8 (0.43) | HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL24473070 | 0.70 | HDAC6 (0.61) | HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL20847479 | 0.68 | HDAC6 (0.74) | HDAC6HDAC8HDAC11HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |