Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375501 | 0.85 | SIGMAR1 (0.56) | LTA4HSIGMAR1 | |
| SCHEMBL7327938 | 0.83 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL21882019 | 0.77 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL19322270 | 0.73 | LTA4H (0.67) | LTA4HEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL1108563 | 0.73 | TAAR1 (0.67) | LTA4HEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL12312565 | 0.72 | SLC2A1 (0.63) | LTA4HEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL28724005 | 0.71 | FFAR1 (0.64) | LTA4HEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL8496409 | 0.70 | LTA4H (0.62) | LTA4HEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL9081140 | 0.70 | LTA4H (0.82) | LTA4HEPHX2 | |
| SCHEMBL8499156 | 0.70 | LTA4H (0.82) | LTA4HEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198062-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |