Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039039 | 0.88 | CYP19A1 (0.76) | CYP19A1CYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL5034929 | 0.82 | CYP19A1 (0.74) | CYP19A1CYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL4349159 | 0.81 | CYP19A1 (0.86) | CYP19A1CYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL30075076 | 0.81 | CYP19A1 (0.86) | CYP19A1CYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL22489742 | 0.81 | CYP19A1 (0.53) | CYP19A1ALDH1A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL22489733 | 0.81 | PRMT6 (0.55) | CYP19A1ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL22489891 | 0.81 | NAMPT (0.54) | CYP19A1CYP3A4ALDH1A1KMT2APOLB | |
| SCHEMBL22489791 | 0.81 | NAMPT (0.54) | CYP19A1ALDH1A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL13623003 | 0.80 | CYP19A1 (0.82) | CYP19A1CYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL28156592 | 0.80 | CYP19A1 (0.82) | CYP19A1CYP1A2CYP3A4CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236055-B2 | Non-systemic TGR5 agonists | Venenum Biodesign, LLC (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200308122-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | Venenum Biodesign, LLC (US) | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308122-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | GPR119, SSTR5, FFAR3 | CYP19A1 2140/4885CYP1A2 2095/4885CYP3A4 2459/4885 |
| US-11236055-B2 | Non-systemic TGR5 agonists | SSTR5, GPR119, FFAR3 | CYP19A1 1627/4885CYP1A2 1864/4885CYP3A4 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.