Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17372930 | 0.87 | SMN1; SMN2 (0.68) | NAMPTCYP19A1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL22489742 | 0.85 | CYP19A1 (0.53) | NAMPTCYP19A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL22489791 | 0.85 | NAMPT (0.54) | NAMPTCYP19A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL22489733 | 0.85 | PRMT6 (0.55) | NAMPTCYP19A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL22467260 | 0.84 | CYP19A1 (0.60) | NAMPTCYP19A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL1846572 | 0.84 | ROCK2 (0.46) | NAMPTCYP19A1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL22489916 | 0.82 | NAMPT (0.57) | NAMPTCYP19A1SMN1; SMN2PRMT6ALDH1A1 | |
| SCHEMBL22489899 | 0.81 | CYP19A1 (0.73) | CYP19A1LMNASMN1; SMN2PRMT6ALDH1A1 | |
| SCHEMBL22489801 | 0.80 | PRMT6 (0.51) | NAMPTCYP19A1LMNASMN1; SMN2PRMT6 | |
| SCHEMBL9954386 | 0.79 | CYP19A1 (0.58) | NAMPTCYP19A1SMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236055-B2 | Non-systemic TGR5 agonists | Venenum Biodesign, LLC (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200308122-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | Venenum Biodesign, LLC (US) | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308122-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | GPR119, SSTR5, FFAR3 | NAMPT 2652/4885CYP19A1 2140/4885LMNA 4662/4885 |
| US-11236055-B2 | Non-systemic TGR5 agonists | SSTR5, GPR119, FFAR3 | NAMPT 2697/4885CYP19A1 1627/4885LMNA 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.