Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27076442 | 0.80 | CACNA1G (0.40) | RAB9ANPC1SMN1; SMN2CYP2C9GCK | |
| SCHEMBL22490239 | 0.75 | NPC1 (0.66) | MTORRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL23213224 | 0.71 | CACNA1G (0.40) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL20744490 | 0.68 | DGAT1 (0.40) | NPC1SMN1; SMN2 | |
| SCHEMBL3531426 | 0.67 | KMT2A (0.32) | RAB9ANPC1SMN1; SMN2CYP2C9GCK | |
| SCHEMBL15300965 | 0.67 | DGAT1 (0.37) | — | |
| SCHEMBL6840285 | 0.67 | LDHB (0.31) | NPC1CYP2C9GCKMAPT | |
| SCHEMBL22468550 | 0.67 | SMN1; SMN2 (0.58) | MTORRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL29477007 | 0.67 | MTOR (0.56) | MTORRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL19926085 | 0.67 | KMT2A (0.49) | RAB9ANPC1SMN1; SMN2CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198053-A1 | 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-01 | — | — | WO | disclosed |