SCHEMBL22490643

SCHEMBL22490643

Clc1cc(Cl)n2ccnc2c1Cl

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 1/20 0.40
GRIN3B O60391 1/20 0.40
GRIA1 P42261 1/20 0.40
GRIA2 P42262 1/20 0.40
GRIA3 P42263 1/20 0.40
GRIA4 P48058 1/20 0.40
GRIN1 Q05586 1/20 0.40
GRIN2A Q12879 1/20 0.40
GRIN2B Q13224 1/20 0.40
GRIN2C Q14957 1/20 0.40
GRIN3A Q8TCU5 1/20 0.40
CCNE1 P24864 2/20 0.34
CDK2 P24941 2/20 0.34
EGLN2 Q96KS0 1/20 0.34
CCNE2 O96020 1/20 0.34
NOTUM Q6P988 2/20 0.33
NUDT1 P36639 1/20 0.30
HRH4 Q9H3N8 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31272820 0.74 GRIN2D (0.38) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL7321101 0.72 GRIN2D (0.34) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL22490646 0.72 CCNE1 (0.38) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL22490653 0.70 GRIN2D (0.35) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL23811383 0.69 L3MBTL1 (0.42) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL22490645 0.67
SCHEMBL22490649 0.67 EGLN2 (0.34) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL10133967 0.65 SSTR4 (0.36) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL18248807 0.65 GRIN2D (0.33) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL30326244 0.65 CCNE1 (0.33) GRIN2DGRIN3BGRIA1GRIA2GRIA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11112366-B2 Reagent and kit for enhancing chemiluminescent reaction NATIONAL TAIWAN OCEAN UNIVERSITY (TW) 2021-09-07 US disclosed
US-20200309707-A1 REAGENT AND KIT FOR ENHANCING CHEMILUMINESCENT REACTION NATIONAL TAIWAN OCEAN UNIVERSITY (TW) 2020-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11112366-B2 Reagent and kit for enhancing chemiluminescent reaction MPO, LPO, KIT GRIN2D 4786/4885GRIN3B 4271/4885GRIA1 3506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.