Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 6/20 | 0.35 |
| ▸ | HTR2B | P41595 | 6/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22491502 | 0.90 | OPRD1 (0.43) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| SCHEMBL2539292 | 0.79 | OPRD1 (0.65) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| Hydrochloric Acid SCHEMBL2310717 | 0.78 | OPRD1 (0.63) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| Bromide SCHEMBL7444095 | 0.78 | OPRD1 (0.63) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| SCHEMBL22491530 | 0.78 | HTR1F (0.42) | OPRD1OPRM1KCNH2HTR2CHTR2B | |
| SCHEMBL8314711 | 0.77 | OPRD1 (0.58) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| Hydrochloric Acid SCHEMBL10600734 | 0.75 | OPRD1 (0.57) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| SCHEMBL22491486 | 0.74 | OPRD1 (0.52) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| SCHEMBL10599177 | 0.73 | OPRD1 (0.58) | OPRD1OPRM1KCNH2ABCB11OPRK1 | |
| SCHEMBL9631918 | 0.73 | OPRD1 (0.58) | OPRD1OPRM1KCNH2ABCB11OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11420961-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3717477-B1 | NEW HETEROCYCLIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2022-07-20 | — | — | EP | disclosed |
| US-20200392125-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2020-12-17 | — | — | US | disclosed |
| EP-3717477-A1 | NEW HETEROCYCLIC COMPOUNDS | H. Hoffnabb-La Roche Ag (CH) | 2020-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11420961-B2 | Heterocyclic compounds | LPXN, MLX, CCNY | OPRD1 1395/4885OPRM1 549/4885KCNH2 578/4885 |
| US-20200392125-A1 | HETEROCYCLIC COMPOUNDS | LPXN, MLX, CCNY | OPRD1 1395/4885OPRM1 549/4885KCNH2 578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.