Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22773295 | 1.00 | PDE4D (0.46) | PDE4DTP53PDE4ALMNAPOLB | |
| SCHEMBL22491593 | 0.87 | GPR119 (0.51) | PDE4DPDE4AMAPTCYP3A4ALDH1A1 | |
| SCHEMBL22773259 | 0.87 | GPR119 (0.51) | PDE4DPDE4AMAPTCYP3A4ALDH1A1 | |
| SCHEMBL22491538 | 0.87 | LMNA (0.50) | PDE4DPDE4ALMNAMGLLALDH1A1 | |
| SCHEMBL22491428 | 0.87 | LMNA (0.50) | PDE4DPDE4ALMNAMGLLALDH1A1 | |
| SCHEMBL22491429 | 0.81 | KDM4E (0.41) | LMNAMGLLALDH1A1SMN1; SMN2 | |
| SCHEMBL22491592 | 0.81 | KDM4E (0.41) | LMNAMGLLALDH1A1SMN1; SMN2 | |
| SCHEMBL21381926 | 0.80 | SLC6A4 (0.51) | PDE4A | |
| SCHEMBL23212042 | 0.79 | CYP3A4 (0.42) | CYP3A4CYP2C9 | |
| SCHEMBL21381659 | 0.79 | CYP3A4 (0.42) | CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717477-A1 | NEW HETEROCYCLIC COMPOUNDS | H. Hoffnabb-La Roche Ag (CH) | 2020-10-07 | — | — | EP | disclosed |