Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 9/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22491538 | 1.00 | LMNA (0.50) | LMNAPDE4AMGLLMEN1KMT2A | |
| SCHEMBL22491574 | 0.87 | PDE4D (0.46) | LMNAPDE4AMGLLALDH1A1PDE4D | |
| SCHEMBL22773295 | 0.87 | PDE4D (0.46) | LMNAPDE4AMGLLALDH1A1PDE4D | |
| SCHEMBL22773261 | 0.86 | MMP13 (0.49) | LMNAPDE4AMEN1KMT2AALDH1A1 | |
| SCHEMBL22491429 | 0.83 | KDM4E (0.41) | LMNAMGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL22491592 | 0.83 | KDM4E (0.41) | LMNAMGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL21381630 | 0.78 | SLC6A4 (0.47) | PDE4AKMT2APDE4BPDE4CPDE4D | |
| SCHEMBL29734316 | 0.78 | SLC6A4 (0.47) | PDE4AKMT2APDE4BPDE4CPDE4D | |
| SCHEMBL23211847 | 0.77 | MGLL (0.64) | MGLL | |
| SCHEMBL30149618 | 0.77 | MGLL (0.64) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717477-A1 | NEW HETEROCYCLIC COMPOUNDS | H. Hoffnabb-La Roche Ag (CH) | 2020-10-07 | — | — | EP | disclosed |