Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356261 | 0.85 | GRM5 (0.45) | GRM5MAPTPOLB | |
| SCHEMBL23400373 | 0.82 | TGFBR1 (0.42) | GRM5NPC1RAB9A | |
| SCHEMBL23402711 | 0.81 | MAPT (0.44) | GRM5NPC1RAB9ANR1H2NR1H3 | |
| SCHEMBL10337766 | 0.80 | MAPT (0.51) | GRM5NPC1RAB9ANR1H2NR1H3 | |
| SCHEMBL14996573 | 0.80 | MAPT (0.52) | GRM5NPC1RAB9ANR1H2NR1H3 | |
| SCHEMBL22510565 | 0.79 | GRM5 (0.49) | GRM5NPC1RAB9AMAPTKMT2A | |
| SCHEMBL23398455 | 0.78 | TDP2 (0.39) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL23402837 | 0.78 | CYP2C9 (0.55) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL23399699 | 0.78 | TDP1 (0.46) | GRM5NPC1RAB9ANR1H2NR1H3 | |
| SCHEMBL23401631 | 0.78 | CNR1 (0.52) | NR1H3MAPTKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11457628-B2 | Substituted pyrimidine compound and preparation method and use thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2022-10-04 | — | — | US | disclosed |
| EP-3828159-A1 | STORAGE AND TRANSPORT STABILIZERS FOR POLYMERIZABLE COMPOUNDS | BASF SE (DE) | 2021-06-02 | — | — | EP | disclosed |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-01-21 | — | — | US | disclosed |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-01-21 | — | — | US | disclosed |
| EP-3719015-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2020-10-07 | — | — | EP | disclosed |
| EP-3719015-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2020-10-07 | — | — | EP | disclosed |
| CN-111263757-A | Substituted pyrimidine compound and preparation method and application thereof | 沈阳中化农药化工研发有限公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-109836417-A | Substituted uracil compound and preparation method thereof and purposes as fungicide | 沈阳中化农药化工研发有限公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-109836418-A | Substituted pyrazolecarboxylic class compound and preparation method thereof and purposes as insecticidal/acaricidal agent | 沈阳中化农药化工研发有限公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-103387541-B | A kind of preparation method of substituted pyrazolecarboxylic ether compound | SINOCHEM CORPORATION (CN) | 2016-02-10 | — | — | CN | disclosed |
| CN-103387542-B | The preparation method of substituted pyrazolecarboxylic ether compound | SINOCHEM CORPORATION (CN) | 2016-01-20 | — | — | CN | disclosed |
| CN-103387542-A | Preparation method of substituted pyrazolylether compound | SINOCHEM CORP | 2013-11-13 | — | — | CN | disclosed |
| CN-103387541-A | Preparation method of substituted pyrazolylether compound | SINOCHEM CORP | 2013-11-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11457628-B2 | Substituted pyrimidine compound and preparation method and use thereof | GART, BROX, APRT | GRM5 2564/4885NPC1 2993/4885RAB9A 516/4885 |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | GART, BROX, APRT | GRM5 2564/4885NPC1 2993/4885RAB9A 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.