SCHEMBL22492971

SCHEMBL22492971

O=C1C(=Cc2ccccc2)SC(=S)N1O

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CISD1 Q9NZ45 4/20 0.67
MAOA P21397 2/20 0.67
MAOB P27338 1/20 0.67
PKM P14618 1/20 0.59
DUSP22 Q9NRW4 6/20 0.58
MAPT P10636 2/20 0.56
DUSP3 P51452 1/20 0.54
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
POLB P06746 1/20 0.53
CASP3 P42574 1/20 0.53
SENP8 Q96LD8 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
SENP6 Q9GZR1 1/20 0.53
MAPK1 P28482 1/20 0.53
ATM Q13315 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27931454 0.83 CISD1 (0.53) CISD1MAOAMAOBPKMDUSP22
SCHEMBL11778921 0.80 CISD1 (1.00) CISD1MAOAMAOBMAPTKMT2A
SCHEMBL12333891 0.80 CISD1 (1.00) CISD1MAOAMAOBMAPTKMT2A
SCHEMBL10801539 0.80 CISD1 (1.00) CISD1MAOAMAOBMAPTKMT2A
SCHEMBL6784135 0.80 CISD1 (0.67) CISD1MAOAMAOBPKMDUSP22
SCHEMBL6784131 0.80 CISD1 (0.67) CISD1MAOAMAOBPKMDUSP22
SCHEMBL9917038 0.79 DUSP22 (0.77) CISD1MAOAMAOBDUSP22MAPT
SCHEMBL12123516 0.79 DUSP22 (0.77) CISD1MAOAMAOBDUSP22MAPT
SCHEMBL10035996 0.79 DUSP22 (0.77) CISD1MAOAMAOBDUSP22MAPT
SCHEMBL9293059 0.78 CRHBP (0.59) PKMDUSP22MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 US claimed
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES (FR) 2022-06-02 US claimed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 EP claimed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 WO claimed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 EP claimed
EP-4747390-A2 PROTEIN EXPRESSION REAGENTS Nuclera Ltd (GB) 2026-05-27 EP disclosed
WO-2026104714-A1 PROTEIN EXPRESSION SYSTEMS NUCLERA LTD (GB) 2026-05-21 WO disclosed
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 US disclosed
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 US disclosed
EP-4713683-A1 A METHOD TO HOMOGENIZE THE CONCENTRATION OF BEADS ACROSS MULTIPLE LIQUID VOLUMES Nuclera Ltd (GB) 2026-03-25 EP disclosed
US-20260072018-A1 PROTEIN BINDING ASSAYS NUCLERA LTD (GB) 2026-03-12 US disclosed
EP-4689663-A1 PROTEIN EXPRESSION SYSTEMS Nuclera Ltd (GB) 2026-02-11 EP disclosed
WO-2022038353-A1 MONITORING OF IN VITRO PROTEIN SYNTHESIS NUCLERA NUCLEICS LTD (GB) 2022-02-24 WO disclosed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 EP disclosed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 EP disclosed
US-20210396762-A1 METHODS FOR PEPTIDE ANALYSIS EMPLOYING MULTI-COMPONENT DETECTION AGENT AND RELATED KITS Encodia, Inc. (US) 2021-12-23 US disclosed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 WO disclosed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 WO disclosed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 EP disclosed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF BLVRB, IK, HBG2 CISD1 720/4885MAOA 2874/4885MAOB 1565/4885
US-20260072018-A1 PROTEIN BINDING ASSAYS EBPL, CYFIP1, YIPF5 CISD1 136/4885MAOA 4581/4885MAOB 4471/4885
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof BLVRB, HBG2, Q6ZSR9 CISD1 758/4885MAOA 2068/4885MAOB 856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.