Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.50 |
| ▸ | GABRE | P78334 | 1/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.50 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28726206 | 0.84 | ABL1 (0.46) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28680173 | 0.84 | GABRP (0.59) | MAPTALDH1A1SMN1; SMN2GABRPGABRD | |
| SCHEMBL28674760 | 0.83 | ABL1 (0.55) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL22396403 | 0.81 | ALDH1A1 (0.53) | MAPTALDH1A1SMN1; SMN2GABRPGABRD | |
| SCHEMBL30410404 | 0.80 | ABL1 (0.56) | ABL1MEN1KMT2AEGLN1EGLN2 | |
| SCHEMBL27449890 | 0.79 | TSHR (0.60) | MAPTALDH1A1SMN1; SMN2GABRPGABRD | |
| SCHEMBL28583536 | 0.77 | LMNA (0.74) | MAPTALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL28672174 | 0.75 | SCN9A (0.47) | MAPTALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL13610176 | 0.74 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2GABRPGABRD | |
| SCHEMBL522362 | 0.74 | EGLN2 (0.59) | LTA4HTHRBEGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592490-B | Preparation method of key intermediate of roxasistat | 浙江工业大学 | 2022-04-22 | — | — | CN | disclosed |
| EP-3717456-A1 | PROCESS FOR THE PREPARATION OF ROXADUSTAT AND ITS INTERMEDIATES | Dr. Reddy's Laboratories Limited (IN) | 2020-10-07 | — | — | EP | disclosed |
| CN-111592490-A | Preparation method of key intermediate of roxasistat | 浙江工业大学 | 2020-08-28 | — | — | CN | disclosed |