Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22494041 | 1.00 | TSHR (0.55) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL22522266 | 0.83 | TSHR (0.52) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL22494001 | 0.82 | TSHR (0.51) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL29548949 | 0.81 | TSHR (0.60) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL22522203 | 0.81 | TSHR (0.50) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL22911393 | 0.81 | TSHR (0.50) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL22522139 | 0.81 | TSHR (0.50) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL1576884 | 0.80 | CA12 (0.50) | TSHRLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL22494014 | 0.79 | TSHR (0.56) | TSHRSMN1; SMN2HPGDLMNAF7 | |
| SCHEMBL22494012 | 0.79 | TSHR (0.56) | TSHRSMN1; SMN2HPGDLMNAF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | Venenum Biodesign, LLC (US) | 2023-02-21 | — | — | US | disclosed |
| US-20220213111-A1 | SUBSTITUTED HETEROCYCLES AS CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2022-07-07 | — | — | US | disclosed |
| US-11306098-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | Venenum Biodesign, LLC (US) | 2022-04-19 | — | — | US | disclosed |
| WO-2022075974-A1 | CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2022-04-14 | — | — | WO | disclosed |
| EP-3953333-A1 | NOVEL CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2022-02-16 | — | — | EP | disclosed |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2021-01-21 | — | — | US | disclosed |
| WO-2020210032-A1 | NOVEL CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC (US) | 2020-10-15 | — | — | WO | disclosed |
| US-20200317677-A1 | NOVEL CYCLIC TREX1 INHIBITORS | Venenum Biodesign, LLC | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317677-A1 | NOVEL CYCLIC TREX1 INHIBITORS | TMX1, TCOF1, TREH | TSHR 343/4885SMN1; SMN2 1798/4885HPGD 2233/4885 |
| US-20220213111-A1 | SUBSTITUTED HETEROCYCLES AS CYCLIC TREX1 INHIBITORS | TMX1, TREH, TSNAX | TSHR 343/4885SMN1; SMN2 1903/4885HPGD 1353/4885 |
| US-11583538-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | TMX1, P2RX1, TCOF1 | TSHR 469/4885SMN1; SMN2 1949/4885HPGD 1881/4885 |
| US-11306098-B2 | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors | TMX1, P2RX1, TCOF1 | TSHR 370/4885SMN1; SMN2 2095/4885HPGD 1780/4885 |
| US-20210015829-A1 | CYCLIC TREX1 INHIBITORS | TMX1, TSNAX, TPX2 | TSHR 363/4885SMN1; SMN2 1847/4885HPGD 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.