Triamcinolone

SCHEMBL22494815

C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)CO)[C@@]2(C)C=CC(=O)C=C12.C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F.[NaH]

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Triamcinolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	6/20	0.68

▸	CYP3A4	P08684	10/20	0.68

▸	HIF1A	Q16665	9/20	0.68

▸	HSD17B10	Q99714	7/20	0.68

▸	PGR	P06401	6/20	0.68

▸	ABCB11	O95342	2/20	0.68

▸	ALDH1A1	P00352	2/20	0.68

▸	ABCC4	O15439	1/20	0.68

▸	NR1I2	O75469	1/20	0.68

▸	PDE4D	Q08499	1/20	0.68

▸	NFKB1	P19838	3/20	0.67

▸	LMNA	P02545	3/20	0.67

▸	CYP2C9	P11712	2/20	0.67

▸	PMP22	Q01453	2/20	0.67

▸	CYP2C19	P33261	2/20	0.67

▸	CYP2J2	P51589	1/20	0.67

▸	BLM	P54132	1/20	0.67

▸	AR	P10275	4/20	0.61

▸	TSHR	P16473	2/20	0.61

▸	NR3C2	P08235	2/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Triamcinolone SCHEMBL3880195	0.99	CYP3A4 (0.69)	CYP3A4HIF1AHSD17B10PGRNR3C1
Betamethasone SCHEMBL20576476	0.95	CYP3A4 (0.69)	CYP3A4HIF1AHSD17B10PGRNR3C1
Dexamethasone SCHEMBL3877338	0.95	CYP3A4 (0.69)	CYP3A4HIF1AHSD17B10PGRNR3C1
Dexamethasone SCHEMBL20767432	0.93	CYP3A4 (0.66)	CYP3A4HIF1AHSD17B10PGRNR3C1
Triamcinolone SCHEMBL5151654	0.91	HIF1A (0.72)	CYP3A4HIF1AHSD17B10PGRNR3C1
Triamcinolone Acetonide SCHEMBL5457484	0.87	CYP3A4 (0.69)	CYP3A4HIF1AHSD17B10PGRNR3C1
Dexamethasone SCHEMBL3309785	0.87	NR3C1 (0.73)	CYP3A4HIF1AHSD17B10PGRNR3C1
Betamethasone SCHEMBL7070539	0.87	NR3C1 (0.73)	CYP3A4HIF1AHSD17B10PGRNR3C1
Beclomethasone SCHEMBL18837977	0.86	CYP3A4 (0.69)	CYP3A4HIF1AHSD17B10PGRNR3C1
Triamcinolone SCHEMBL593313	0.84	HIF1A (0.68)	CYP3A4HIF1AHSD17B10PGRNR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20200317783-A1	BISPECIFIC ANTIBODY	ONO PHARMACEUTICAL CO., LTD. (JP)	2020-10-08	—	—	US	disclosed