Triamcinolone Acetonide

SCHEMBL5457484

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)CO)[C@@]2(C)C=CC(=O)C=C12

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Triamcinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.69

▸	CYP3A4	P08684	9/20	0.69

▸	PGR	P06401	7/20	0.69

▸	LMNA	P02545	6/20	0.69

▸	HIF1A	Q16665	6/20	0.69

▸	NR1I2	O75469	2/20	0.69

▸	HSD17B10	Q99714	4/20	0.62

▸	ABCB11	O95342	3/20	0.62

▸	ALDH1A1	P00352	1/20	0.62

▸	ABCC4	O15439	1/20	0.62

▸	PDE4D	Q08499	1/20	0.62

▸	KDM4E	B2RXH2	2/20	0.58

▸	CYP2C19	P33261	1/20	0.58

▸	HTR1A	P08908	1/20	0.58

▸	ADRA2A	P08913	1/20	0.58

▸	ADRA1A	P35348	1/20	0.58

▸	NPSR1	Q6W5P4	2/20	0.57

▸	MAPT	P10636	2/20	0.56

▸	AR	P10275	2/20	0.56

▸	TDP1	Q9NUW8	1/20	0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Triamcinolone SCHEMBL3880195	0.88	CYP3A4 (0.69)	CYP3A4NR3C1PGRLMNAHIF1A
Triamcinolone Acetonide SCHEMBL20915153	0.88	HIF1A (0.77)	CYP3A4NR3C1PGRLMNAHIF1A
Triamcinolone SCHEMBL22494815	0.87	CYP3A4 (0.68)	CYP3A4NR3C1PGRLMNAHIF1A
Betamethasone SCHEMBL20576476	0.87	CYP3A4 (0.69)	CYP3A4NR3C1PGRLMNAHIF1A
Dexamethasone SCHEMBL3877338	0.87	CYP3A4 (0.69)	CYP3A4NR3C1PGRLMNAHIF1A
Triamcinolone Acetonide SCHEMBL17785112	0.86	HIF1A (0.76)	CYP3A4NR3C1PGRLMNAHIF1A
Flunisolide SCHEMBL20915050	0.85	CYP3A4 (0.69)	CYP3A4NR3C1PGRLMNAHIF1A
Dexamethasone SCHEMBL20767432	0.85	CYP3A4 (0.66)	CYP3A4NR3C1PGRLMNAHIF1A
Triamcinolone Acetonide SCHEMBL11911289	0.83	HIF1A (1.00)	CYP3A4NR3C1PGRLMNAHIF1A
Triamcinolone Acetonide SCHEMBL1639690	0.83	HIF1A (1.00)	CYP3A4NR3C1PGRLMNAHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20070049901-A1	Method of treating acne with stratum corneum piercing device	JOHNSON & JOHNSON CONSUMER COMPANIES, INC.	2007-03-01	—	—	US	disclosed