Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 8/20 | 0.46 |
| ▸ | ME2 | P23368 | 3/20 | 0.44 |
| ▸ | ME1 | P48163 | 3/20 | 0.44 |
| ▸ | ME3 | Q16798 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19748850 | 0.85 | PANK3 (0.61) | PANK3PARP1PARP2CHRM4 | |
| SCHEMBL3075325 | 0.81 | CNR2 (0.58) | PANK3PARP1PARP2CHRM4 | |
| SCHEMBL5916431 | 0.80 | ADK (0.56) | PANK3SMN1; SMN2ADK | |
| SCHEMBL578498 | 0.78 | HTR3A (0.47) | PARP1ALDH1A1L3MBTL1 | |
| SCHEMBL21551525 | 0.78 | ME2 (0.66) | ME2ME1ME3AKR1C3LMNA | |
| SCHEMBL29108005 | 0.78 | MAPT (0.49) | PARP1LMNAMAPTADKALDH1A1 | |
| SCHEMBL30665755 | 0.78 | MAPT (0.49) | PARP1LMNAMAPTADKALDH1A1 | |
| SCHEMBL1904842 | 0.78 | GRM5 (0.59) | ME2ME1ME3ALDH1A1 | |
| SCHEMBL3832779 | 0.77 | ME2 (0.47) | ME2ME1ME3AKR1C3LMNA | |
| SCHEMBL16397570 | 0.77 | PANK3 (0.57) | PANK3ME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11541132-B2 | Radiolabeled compounds | HOFFMANN-LA ROCHE INC. (US) | 2023-01-03 | — | — | US | disclosed |
| EP-3728234-A1 | RADIOLABELED COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2020-10-28 | — | — | EP | disclosed |
| US-20200316232-A1 | RADIOLABELED COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541132-B2 | Radiolabeled compounds | SNCA, APP, BACE1 | PANK3 4765/4885ME2 3836/4885ME1 4227/4885 |
| US-20200316232-A1 | RADIOLABELED COMPOUNDS | SNCA, APP, BACE1 | PANK3 4767/4885ME2 3940/4885ME1 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.