SCHEMBL22497943

SCHEMBL22497943

CC(N)c1nccnc1-c1ncc(OCC(F)(F)F)cn1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CACNA1I Q9P0X4 3/20 0.37
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
CYP17A1 P05093 2/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
CACNA1G O43497 2/20 0.32
CACNA1H O95180 2/20 0.32
CNR2 P34972 2/20 0.32
KCNH2 Q12809 1/20 0.32
AAK1 Q2M2I8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29434507 1.00 CACNA1I (0.37) CACNA1IALDH1A1MAPTCYP17A1CYP2C9
SCHEMBL29434524 0.83 CACNA1I (0.41) CACNA1IALDH1A1MAPTCYP17A1CYP2C9
SCHEMBL22497946 0.83 CACNA1I (0.41) CACNA1IALDH1A1MAPTCYP17A1CYP2C9
SCHEMBL22497940 0.82
SCHEMBL29434501 0.82
SCHEMBL24514029 0.81 CACNA1I (0.43) CACNA1IALDH1A1MAPTCYP17A1CYP2C9
SCHEMBL22497928 0.78 GAA (0.31) MAPT
SCHEMBL29434512 0.78 GAA (0.31) MAPT
SCHEMBL10258136 0.74 ALDH1A1 (0.42) CACNA1IALDH1A1MAPTCYP17A1CYP2C9
SCHEMBL16089011 0.74 ALDH1A1 (0.42) CACNA1IALDH1A1MAPTCYP17A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3947358-B1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-06-18 EP disclosed
US-12281095-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2025-04-22 US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 US disclosed
US-20220169629-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-02 US disclosed
US-20220169629-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-02 US disclosed
EP-3953343-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-02-16 EP disclosed
EP-3947358-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-02-09 EP disclosed
CN-113677672-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-19 CN disclosed
CN-113631549-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-09 CN disclosed
WO-2020208036-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-15 WO disclosed
WO-2020208036-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-15 WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 CACNA1I 212/4885ALDH1A1 787/4885MAPT 674/4885
US-12281095-B2 Pesticidally active diazine-amide compounds DDT, ACHE, NIT2 CACNA1I 212/4885ALDH1A1 787/4885MAPT 674/4885
US-20220169629-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 CACNA1I 217/4885ALDH1A1 1134/4885MAPT 569/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.