SCHEMBL22497946

SCHEMBL22497946

CC(N)c1nccnc1-c1ccc(OCC(F)(F)F)cn1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CACNA1I Q9P0X4 3/20 0.41
CACNA1G O43497 2/20 0.37
CACNA1H O95180 2/20 0.37
CNR2 P34972 1/20 0.37
KCNH2 Q12809 1/20 0.37
CYP2C9 P11712 3/20 0.36
CYP17A1 P05093 3/20 0.36
CYP2C19 P33261 2/20 0.36
AAK1 Q2M2I8 2/20 0.34
TRPV3 Q8NET8 1/20 0.34
CYP1A2 P05177 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 1/20 0.33
DGAT1 O75907 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29434524 1.00 CACNA1I (0.41) CACNA1ICACNA1GCACNA1HCNR2KCNH2
SCHEMBL24514029 0.83 CACNA1I (0.43) CACNA1ICYP2C9CYP17A1CYP2C19AAK1
SCHEMBL22497943 0.83 CACNA1I (0.37) CACNA1ICACNA1GCACNA1HCNR2KCNH2
SCHEMBL29434507 0.83 CACNA1I (0.37) CACNA1ICACNA1GCACNA1HCNR2KCNH2
SCHEMBL29776067 0.81 PDCD1 (0.37) ALDH1A1
SCHEMBL23212689 0.81 PDCD1 (0.37) ALDH1A1
SCHEMBL29776077 0.80 NPSR1 (0.39) TRPV3CYP1A2ALDH1A1
SCHEMBL23213901 0.80 NPSR1 (0.39) TRPV3CYP1A2ALDH1A1
SCHEMBL20484982 0.75 CACNA1I (0.51) CACNA1ICACNA1GCACNA1HCNR2KCNH2
SCHEMBL22510411 0.75 TGFBR1 (0.38) TRPV3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3947358-B1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-06-18 EP disclosed
US-12281095-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2025-04-22 US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 US disclosed
US-20220169629-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-02 US disclosed
US-20220169629-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-02 US disclosed
EP-3953343-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-02-16 EP disclosed
EP-3947358-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-02-09 EP disclosed
CN-113677672-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-19 CN disclosed
CN-113631549-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-09 CN disclosed
WO-2020208036-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-15 WO disclosed
WO-2020208036-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-15 WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 CACNA1I 212/4885CACNA1G 322/4885CACNA1H 309/4885
US-12281095-B2 Pesticidally active diazine-amide compounds DDT, ACHE, NIT2 CACNA1I 212/4885CACNA1G 322/4885CACNA1H 309/4885
US-20220169629-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 CACNA1I 217/4885CACNA1G 389/4885CACNA1H 426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.