SCHEMBL225

SCHEMBL225

CCCCc1nc(Cl)c(CO)[nH]1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
MAPK1 P28482 1/20 0.41
GPR84 Q9NQS5 5/20 0.38
PARP1 P09874 1/20 0.36
GSK3B P49841 1/20 0.34
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
PI4KA P42356 1/20 0.33
PI4K2B Q8TCG2 1/20 0.33
PI4K2A Q9BTU6 1/20 0.33
PI4KB Q9UBF8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL129 0.93 GPR84 (0.45) ALDH1A1MAPK1GPR84KMT2API4KA
SCHEMBL9081842 0.93 GPR84 (0.45) ALDH1A1MAPK1GPR84KMT2API4KA
SCHEMBL606 0.89 PDK2 (0.37) GPR84KDM4EMEN1KMT2A
Succinchlorimide SCHEMBL9385981 0.85 GPR84 (0.35) ALDH1A1MAPK1GPR84PARP1GSK3B
SCHEMBL8790906 0.84 ALDH1A1 (0.42) ALDH1A1MAPK1GPR84PARP1GSK3B
SCHEMBL3027998 0.81 GAA (0.39) KDM4EMEN1KMT2A
SCHEMBL4356446 0.80 ALDH1A1 (0.42) ALDH1A1MAPK1GPR84PARP1GSK3B
SCHEMBL9592755 0.79 GPR84 (0.37) ALDH1A1MAPK1GPR84PARP1GSK3B
SCHEMBL9083256 0.79 ALDH1A1 (0.41) ALDH1A1MAPK1GPR84PARP1GSK3B
SCHEMBL8435741 0.79 ALDH1A1 (0.41) ALDH1A1MAPK1GPR84PARP1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119215691-A Ion modified liquid and preparation method and application thereof 佛山市麦克罗美的滤芯设备制造有限公司 2024-12-31 CN claimed
CN-117174859-A Low-cost high-capacity coal-based hard carbon composite material and preparation method and application thereof 常州烯源谷新材料科技有限公司 2023-12-05 CN claimed
CN-116410139-A Preparation method of losartan impurity 润都制药(荆门)有限公司 2023-07-11 CN claimed
US-20140031289-A1 POLY(ORGANOPHOSPHAZENE) CONTAINING DEGRADATION CONTROLLABLE IONIC GROUP, PREPARATION METHOD THEREOF AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2014-01-30 US claimed
CN-101328167-B Preparation method of losartan BEIJING SECOND PHARMACEUTICAL CO LTD 2012-04-25 CN claimed
CN-1915990-B Method for preparingLosartan HAIZHENG PHARMACEUTICAL IND CO LTD ZHEJIANG 2011-07-13 CN claimed
US-20090056795-A1 ELECTROLYTE FOR SOLAR CELL AND SOLAR CELL HAVING THE SAME SAMSUNG SDI CO., LTD. (KR) 2009-03-05 US claimed
CN-1915990-A Method for preparingLosartan HAIZHENG PHARMACEUTICAL IND CO (CN) 2007-02-21 CN claimed
JP-2007501770-A 2007-02-01 JP claimed
EP-1660463-A1 A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES Dipharma S.p.A. (IT) 2006-05-31 EP claimed
WO-2005014560-A1 A PROCESS FOR THE PREPARATION OF PHENYLTETRAZOLE DERIVATIVES DIPHARMA S.P.A. (IT) 2005-02-17 WO claimed
JP-7053524-A None JP disclosed
CN-119215691-A Ion modified liquid and preparation method and application thereof 佛山市麦克罗美的滤芯设备制造有限公司 2024-12-31 CN disclosed
CN-117174859-A Low-cost high-capacity coal-based hard carbon composite material and preparation method and application thereof 常州烯源谷新材料科技有限公司 2023-12-05 CN disclosed
CN-117143023-A Preparation method of imidazole aldehyde and recrystallization process 云南云天化股份有限公司 2023-12-01 CN disclosed
WO-1989006233-A1 ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-07-13 WO disclosed
EP-0253310-A2 Angiotensin II receptor blocking imidazoles E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-20 EP disclosed
EP-0028833-B1 IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1984-01-25 EP disclosed
US-4340598-A Hypotensive imidazole derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1982-07-20 US disclosed
EP-0028833-A2 Imidazole derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1981-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140031289-A1 POLY(ORGANOPHOSPHAZENE) CONTAINING DEGRADATION CONTROLLABLE IONIC GROUP, PREPARATION METHOD THEREOF AND USE THEREOF PHOSPHO1, PLCB3, INPP5D ALDH1A1 4053/4885MAPK1 1786/4885GPR84 1362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.