Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Deflazacort. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.98 |
| ▸ | PGR | P06401 | 7/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deflazacort SCHEMBL24497637 | 0.99 | NR3C1 (1.00) | NR3C1PGRHIF1ANR1I2CNR1 | |
| Deflazacort SCHEMBL4018 | 0.99 | NR3C1 (1.00) | NR3C1PGRHIF1ANR1I2CNR1 | |
| Deflazacort SCHEMBL2598076 | 0.99 | NR3C1 (1.00) | NR3C1PGRHIF1ANR1I2CNR1 | |
| Deflazacort SCHEMBL4019 | 0.99 | NR3C1 (1.00) | NR3C1PGRHIF1ANR1I2CNR1 | |
| Deflazacort SCHEMBL4259541 | 0.97 | NR3C1 (0.95) | NR3C1PGRHIF1ANR1I2CNR1 | |
| Deflazacort SCHEMBL17941674 | 0.96 | NR3C1 (0.94) | NR3C1PGRHIF1ANR1I2CNR1 | |
| SCHEMBL13653579 | 0.92 | NR3C1 (0.86) | NR3C1PGRHIF1ANR1I2CNR1 | |
| Deflazacort SCHEMBL887173 | 0.91 | NR3C1 (0.84) | NR3C1PGRHIF1ANR1I2LMNA | |
| 21-Desacetyldeflazacort SCHEMBL30754690 | 0.89 | NR3C1 (0.81) | NR3C1PGRHIF1ANR1I2CNR1 | |
| SCHEMBL13653592 | 0.88 | NR3C1 (0.80) | NR3C1PGRHIF1ANR1I2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411825-A1 | METHOD OF ENGINEERING HYPOIMMUNOGENIC MUSCLE PRECURSOR CELLS | VITA THERAPEUTICS, INC. (US) | 2022-12-29 | — | — | US | disclosed |
| EP-3945827-A2 | METHODS, COMPOSITIONS, AND KITS FOR PRODUCING SKELETAL MUSCLE STEM CELLS AND TREATING DISORDERS | The Johns Hopkins University (US) | 2022-02-09 | — | — | EP | disclosed |
| WO-2021102324-A1 | METHOD OF ENGINEERING HYPOIMMUNOGENIC MUSCLE PRECURSOR CELLS | VITA THERAPEUTICS, INC. (US) | 2021-05-27 | — | — | WO | disclosed |
| WO-2020206272-A2 | METHODS, COMPOSITIONS, AND KITS FOR PRODUCING SKELETAL MUSCLE STEM CELLS AND TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-10-08 | — | — | WO | disclosed |