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Deflazacort

Deflazacort

SCHEMBL887173

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nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Deflazacort. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 9/20 0.84
▸ PGR P06401 8/20 0.84
▸ HIF1A Q16665 6/20 0.71
▸ CYP3A4 P08684 5/20 0.67
▸ HSD17B10 Q99714 4/20 0.67
▸ AR P10275 4/20 0.67
▸ ABCB11 O95342 3/20 0.67
▸ SERPINA6 P08185 2/20 0.67
▸ NR3C2 P08235 2/20 0.67
▸ TNF P01375 1/20 0.67
▸ IL6 P05231 1/20 0.67
▸ GLUL P15104 1/20 0.67
▸ ADAM17 P78536 1/20 0.67
▸ GPBAR1 Q8TDU6 1/20 0.67
▸ CYP2C19 P33261 1/20 0.67
▸ LMNA P02545 3/20 0.58
▸ F2 P00734 1/20 0.56
▸ CHRM1 P11229 2/20 0.52
▸ KMT2A Q03164 1/20 0.52
▸ ABCC4 O15439 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Deflazacort SCHEMBL4019 0.92 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Deflazacort SCHEMBL24497637 0.92 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Deflazacort SCHEMBL2598076 0.92 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Deflazacort SCHEMBL4018 0.92 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Deflazacort SCHEMBL4259541 0.91 NR3C1 (0.95) NR3C1PGRHIF1ACYP3A4HSD17B10
Deflazacort SCHEMBL22502722 0.91 NR3C1 (0.98) NR3C1PGRHIF1ACYP3A4HSD17B10
Deflazacort SCHEMBL17941674 0.89 NR3C1 (0.94) NR3C1PGRHIF1ACYP3A4HSD17B10
Prednisolone Acetate SCHEMBL9806568 0.87 HIF1A (0.93) NR3C1PGRHIF1ACYP3A4HSD17B10
Prednisolone Acetate SCHEMBL9806574 0.87 HIF1A (0.93) NR3C1PGRHIF1ACYP3A4HSD17B10
21-Desacetyldeflazacort SCHEMBL30754690 0.87 NR3C1 (0.81) NR3C1PGRHIF1ACYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011146819-A2 METHODS AND COMPOSITIONS FOR TREATMENT NF-κB-MEDIATED AND α7 INTEGRIN-SUPPRESSED DISEASES DMD THERAPIES, LLC (US) 2011-11-24 — — WO disclosed
US-20110217715-A1 GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2011-09-08 — — US disclosed
EP-2344670-A1 GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY Children's Hospital Medical Center (US) 2011-07-20 — — EP disclosed
US-20100105054-A1 GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2010-04-29 — — US disclosed
WO-2010045405-A1 GENE EXPRESSION IN DUCHENNE MUSCULAR DYSTROPHY CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2010-04-22 — — WO disclosed