Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.88 |
| ▸ | CCR1 | P32246 | 3/20 | 0.88 |
| ▸ | CCR5 | P51681 | 3/20 | 0.88 |
| ▸ | CCR8 | P51685 | 3/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.88 |
| ▸ | POLB | P06746 | 1/20 | 0.88 |
| ▸ | METAP1 | P53582 | 1/20 | 0.88 |
| ▸ | BLM | P54132 | 1/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.88 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.88 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.88 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | TP53 | P04637 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL3751791 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL29768749 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL196501 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL29728717 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL230578 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL35210403 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL30635227 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL9644480 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL809479 | 0.94 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8687972 | 0.94 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6073169-A | — | — | None | — | — | JP | disclosed |
| EP-1916244-B1 | THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME | NISSAN CHEMICAL IND LTD (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-1882694-B1 | OLIGOMERS AND POLYMERS OF THIOPHENE COMPOUNDS HAVING PHOSPHORIC ESTER AND PROCESS FOR PRODUCING THE SAME | NISSAN CHEMICAL IND LTD (JP) | 2013-04-03 | — | — | EP | disclosed |
| EP-1348716-B1 | Aromatic polymer, method for producing the same and uses thereof | SUMITOMO CHEMICAL CO (JP) | 2011-10-12 | — | — | EP | disclosed |
| US-8030438-B2 | Thiophene compound having phosphoric ester and process for producing the same | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-8008425-B2 | Thiophene compound having sulfonyl group and process for producing the same | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-08-30 | — | — | US | disclosed |
| US-20100019229-A1 | Thiophene compound having phosphoric ester and process for producing the same | NISSAN CHEMICAL INDUSTRIES, LTD (JP) | 2010-01-28 | — | — | US | disclosed |
| US-20090127491-A1 | THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
| EP-1916244-A1 | THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME | Nissan Chemical Industries, Ltd. (JP) | 2008-04-30 | — | — | EP | disclosed |
| EP-1882694-A1 | THIOPHENE COMPOUND HAVING PHOSPHORIC ESTER AND PROCESS FOR PRODUCING THE SAME | Nissan Chemical Industries, Ltd. (JP) | 2008-01-30 | — | — | EP | disclosed |
| EP-1348716-A1 | Aromatic polymer, method for producing the same and uses thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-10-01 | — | — | EP | disclosed |
| US-20030180596-A1 | Aromatic polymer, method for producing the same and uses thereof | SUMITOMO CHEMICAL COMPANY, LIMITED | 2003-09-25 | — | — | US | disclosed |
| US-6197923-B1 | N-OXIDATED POLYPYRIDINES, POLYPYRIMIDINES, POLYPYRAZINES, POLYPYRIDAZINES, POLYQUINOLINES, POLYQUINOXALINES, POLYQUINAZOLINES, AND POLYNAPHTHRYDINES; SEMICONDUCTORS; HEAT RESISTANCE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| US-5548048-A | Process for manufacturing alkyl-substituted poly (2,2'-diyl) bipyridine-5,5'-diyl | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1996-08-20 | — | — | US | disclosed |
| US-5475082-A | Use of poly(alkylpyridine-2,5-diyl) | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1995-12-12 | — | — | US | disclosed |
| US-5436316-A | Poly(alkylpyridine-2,5-diyl) and preparation thereof | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1995-07-25 | — | — | US | disclosed |
| US-5424381-A | Alkyl-substituted poly(2,2'-bipyridine-5,5'-diyl) and use thereof | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5367038-A | Polyisoquinolinediyls and uses thereof | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1994-11-22 | — | — | US | disclosed |
| JP-H0673169-A | POLY@(3754/24)ALKYLPYRIDIN-2,5-DIYL) POLYMER, ITS PRODUCTION AND METHOD FOR UTILIZING THE SAME POLYMER | TOKYO INST OF TECHNOL | 1994-03-15 | — | — | JP | disclosed |
| US-5244992-A | Poly(iso)quinolinediyls and preparation and use thereof | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 1993-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100019229-A1 | Thiophene compound having phosphoric ester and process for producing the same | RRP12, NR2E1, TST | KDM4E 3208/4885LMNA 4870/4885CCR1 2068/4885 |
| US-20090127491-A1 | THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME | TST, ABCG2, CBR3 | KDM4E 2440/4885LMNA 4827/4885CCR1 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.