Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLRE1B | Q9H816 | 2/20 | 0.54 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.52 |
| ▸ | RARB | P10826 | 2/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | BAD | Q92934 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251799 | 0.97 | DCLRE1B (0.57) | DCLRE1BDCLRE1AHCAR2RARBRARA | |
| SCHEMBL2254822 | 0.92 | DCLRE1B (0.56) | DCLRE1BDCLRE1AHCAR2BCL2L1BAD | |
| SCHEMBL2253118 | 0.90 | BCL2L1 (0.56) | DCLRE1BDCLRE1AHCAR2RARBRARA | |
| SCHEMBL2255248 | 0.88 | SOX18 (0.50) | DCLRE1BDCLRE1AHCAR2RARBRARA | |
| SCHEMBL2258533 | 0.88 | PTPN1 (0.50) | DCLRE1BDCLRE1AHCAR2BCL2L1BAD | |
| SCHEMBL2257940 | 0.85 | ELOVL1 (0.49) | DCLRE1BDCLRE1AADRB3 | |
| SCHEMBL2257377 | 0.84 | ADRB3 (0.43) | DCLRE1BDCLRE1AHCAR2RARBRARA | |
| SCHEMBL2252452 | 0.83 | BCL2L1 (0.46) | DCLRE1BDCLRE1AHCAR2RARBRARA | |
| SCHEMBL2258585 | 0.82 | PTPN1 (0.47) | DCLRE1BDCLRE1AHCAR2RARBRARA | |
| SCHEMBL12062912 | 0.82 | NR4A2 (0.46) | BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904047-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100234456-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750004-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2010-07-06 | — | — | US | disclosed |
| US-20070135392-A1 | Apoptosis promoters | ABBVIE INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234456-A1 | APOPTOSIS PROMOTERS | MCL1, BAX, BCL2 | DCLRE1B 129/4885DCLRE1A 270/4885HCAR2 4597/4885 |
| US-20070135392-A1 | Apoptosis promoters | MCL1, BAX, BCL2 | DCLRE1B 129/4885DCLRE1A 270/4885HCAR2 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.