Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 7/20 | 0.54 |
| ▸ | POLG | P54098 | 1/20 | 0.52 |
| ▸ | P2RY4 | P51582 | 4/20 | 0.51 |
| ▸ | P2RY6 | Q15077 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.45 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22678641 | 0.91 | POLG (0.62) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL16807802 | 0.91 | POLG (0.62) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL6715777 | 0.91 | POLG (0.62) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL6715771 | 0.91 | POLG (0.62) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL6258019 | 0.91 | POLG (0.59) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL18383663 | 0.90 | P2RY2 (0.53) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL18102349 | 0.89 | POLB (0.49) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL21895965 | 0.87 | POLB (0.56) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL21896183 | 0.87 | POLB (0.56) | P2RY2POLGP2RY4P2RY6POLB | |
| SCHEMBL12648719 | 0.87 | POLB (0.56) | P2RY2POLGP2RY4P2RY6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947408-B1 | SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS | NuCana plc (GB) | 2023-06-07 | — | — | EP | disclosed |
| WO-2020201751-A1 | SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS | NuCana plc (GB) | 2020-10-08 | — | — | WO | disclosed |