⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931740 | 0.84 | — | — | |
| SCHEMBL930736 | 0.84 | — | — | |
| SCHEMBL7743557 | 0.80 | — | — | |
| SCHEMBL930678 | 0.78 | — | — | |
| SCHEMBL1066665 | 0.77 | TSHR (0.35) | — | |
| SCHEMBL2241328 | 0.76 | — | — | |
| SCHEMBL11244947 | 0.76 | — | — | |
| SCHEMBL28314978 | 0.76 | TSHR (0.36) | — | |
| SCHEMBL8992662 | 0.74 | KDM1A (0.31) | — | |
| SCHEMBL4199404 | 0.74 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367855-B2 | Process for preparing silylorganoamines | EVONIK DEGUSSA GMBH (DE) | 2013-02-05 | — | — | US | disclosed |
| EP-2361916-B1 | Method for manufacturing silylorganoamines | EVONIK DEGUSSA GMBH (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2361916-A1 | Method for manufacturing silylorganoamines | Evonik Degussa GmbH (DE) | 2011-08-31 | — | — | EP | disclosed |
| EP-2361917-A1 | Method for manufacturing silylorganoamines | Evonik Degussa GmbH (DE) | 2011-08-31 | — | — | EP | disclosed |
| US-20110201835-A1 | Process for Preparing Silylorganoamines | EVONIK DEGUSSA GMBH (DE) | 2011-08-18 | — | — | US | disclosed |