Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 5/20 | 0.38 |
| ▸ | HNF4A | P41235 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254743 | 0.73 | GRIN2D (0.42) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2255104 | 0.73 | BCL2L1 (0.67) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2257615 | 0.73 | SOX18 (0.46) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2255199 | 0.73 | AKR1C3 (0.47) | GRIN2DGRIN2AGRIN2BGRIN2CMCL1 | |
| SCHEMBL2255098 | 0.73 | BCL2L1 (0.67) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2257660 | 0.72 | ACLY (0.49) | GRIN2DGRIN2AGRIN2BGRIN2CMEN1 | |
| SCHEMBL2253800 | 0.72 | ACLY (0.50) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2254380 | 0.72 | DCLRE1B (0.43) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2256052 | 0.70 | BCL2L1 (0.51) | GRIN2DGRIN2AGRIN2BGRIN2CBCL2L1 | |
| SCHEMBL2255077 | 0.70 | ACLY (0.52) | MEN1KMT2APPARASTING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904047-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100234456-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750004-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2010-07-06 | — | — | US | disclosed |
| US-20070135392-A1 | Apoptosis promoters | ABBVIE INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234456-A1 | APOPTOSIS PROMOTERS | MCL1, BAX, BCL2 | GRIN2D 4683/4885GRIN2A 3979/4885GRIN2B 3985/4885 |
| US-20070135392-A1 | Apoptosis promoters | MCL1, BAX, BCL2 | GRIN2D 4683/4885GRIN2A 3979/4885GRIN2B 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.