Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530830 | 0.87 | APLNR (0.54) | APLNRTP53TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL11300017 | 0.87 | TP53 (0.55) | APLNRTP53ALDH1A1TSHRNPSR1 | |
| SCHEMBL28970344 | 0.85 | APLNR (0.58) | APLNRTP53ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL28452492 | 0.83 | APLNR (0.63) | APLNRTP53TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL22537209 | 0.82 | APLNR (0.57) | APLNRTP53ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL12494088 | 0.81 | APLNR (0.52) | APLNRTP53TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL11954292 | 0.80 | TP53 (0.46) | APLNRTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12492811 | 0.80 | ALDH1A1 (0.53) | APLNRTP53TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL21827126 | 0.79 | APLNR (0.54) | APLNRTP53TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL1530735 | 0.79 | APLNR (0.65) | APLNRTP53ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |