Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851604 | 0.78 | PDE2A (0.48) | ACACBHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL608849 | 0.78 | ACACB (0.44) | ACACBGAAOGA | |
| SCHEMBL14808848 | 0.78 | ACACB (0.44) | ACACBKDM4EMAPTHDAC3HDAC1 | |
| SCHEMBL21016975 | 0.76 | HCAR3 (0.47) | ACACBGAAKDM4EMAPTKMT2A | |
| SCHEMBL27254652 | 0.75 | ACACB (0.54) | ACACBGAAMAPTHDAC1CYP2C9 | |
| SCHEMBL21016981 | 0.75 | ACACB (0.42) | ACACBKDM4EMAPTKMT2AOGA | |
| SCHEMBL2253745 | 0.74 | TRPV4 (0.50) | GAATRPV4KMT2ACYP2C9SLC22A6 | |
| SCHEMBL77362 | 0.74 | TRPV4 (0.54) | GAATRPV4KMT2ACYP2C9SLC22A6 | |
| SCHEMBL23768156 | 0.73 | HCAR3 (0.51) | ACACBKDM4EMAPTKMT2AOGA | |
| SCHEMBL9906890 | 0.72 | KDM4E (0.55) | GAAKDM4EMAPTKMT2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099784-B1 | 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDRIOYRROLIDIN-2-ONES AS CB1 RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2099784-B1 | 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDRIOYRROLIDIN-2-ONES AS CB1 RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-12-12 | — | — | EP | disclosed |
| US-8168659-B2 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators | ELI LILLY AND COMPANY (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168659-B2 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators | ELI LILLY AND COMPANY (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168659-B2 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators | ELI LILLY AND COMPANY (US) | 2012-05-01 | — | — | US | disclosed |
| US-7998985-B2 | 1,5-diphenyl-3-pyridinylamino-1,5-dihydropyrrolidin-2-one as CB1 receptor modulator | ELI LILLY AND COMPANY (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998985-B2 | 1,5-diphenyl-3-pyridinylamino-1,5-dihydropyrrolidin-2-one as CB1 receptor modulator | ELI LILLY AND COMPANY (US) | 2011-08-16 | — | — | US | disclosed |
| EP-2094684-B1 | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN 2-ONES AS CB1 RECEPTOR MODULATORS | LILLY CO ELI (US) | 2010-12-22 | — | — | EP | disclosed |
| EP-2094684-B1 | 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN 2-ONES AS CB1 RECEPTOR MODULATORS | LILLY CO ELI (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20100016375-A1 | 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATOR | ELI LILLY AND COMPANY | 2010-01-21 | — | — | US | disclosed |
| US-20100016375-A1 | 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATOR | ELI LILLY AND COMPANY | 2010-01-21 | — | — | US | disclosed |
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2009-11-05 | — | — | US | disclosed |
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2009-11-05 | — | — | US | disclosed |
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2009-11-05 | — | — | US | disclosed |
| WO-2008070305-A2 | 1, 5-DIPHENYL-3-PYRIDINYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CBL' RECEPTOR MODULATOR | ELI LILLY AND COMPANY (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008070306-A2 | 1,5-DIPHENYL-3-BENZYLAMIN0-1,5-DIHYDR0PYRR0LIDIN-2-0NE AS CB1 RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275618-A1 | 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS | CNR1, CNR2, GPR55 | ACACB 2389/4885GAA 3424/4885DGAT2 275/4885 |
| US-20100016375-A1 | 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATOR | CNR1, CNR2, GPR55 | ACACB 2351/4885GAA 3987/4885DGAT2 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.