Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Benzoxonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29742981 | 1.00 | MEN1 (0.61) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL25330890 | 1.00 | MEN1 (0.61) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL10717901 | 1.00 | MEN1 (0.61) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL27172705 | 0.98 | DNM1 (0.60) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Benzoxonium SCHEMBL3939819 | 0.98 | DNM1 (0.60) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL27172704 | 0.98 | DNM1 (0.60) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL11333079 | 0.92 | DNM1 (0.60) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL28468864 | 0.92 | DNM1 (0.50) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL28467626 | 0.92 | DNM1 (0.50) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL2059990 | 0.92 | MEN1 (0.71) | MEN1KMT2ATP53SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2546 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260048003-A1 | STABLE CYCLODEXTRIN FREE CARFILZOMIB FORMULATION | AMGEN INC (US) | 2026-02-19 | — | — | US | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-115926141-B | Preparation method of cation-pi type coating modified carbon fiber and carbon fiber composite material | 长春工业大学 | 2025-01-21 | — | — | CN | claimed |
| CN-118185507-B | Multilayer embossing precoating film and preparation method thereof | 扬州市众和同盛包装材料有限公司 | 2024-09-20 | — | — | CN | claimed |
| CN-118185507-A | Multilayer embossing precoating film and preparation method thereof | 扬州市众和同盛包装材料有限公司 | 2024-06-14 | — | — | CN | claimed |
| US-20240173512-A1 | METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS | STREETERVILLE CAPITAL, LLC | 2024-05-30 | — | — | US | claimed |
| US-11903992-B2 | Composition comprising lidocaine, l-carnosine and dexpanthenol | CELLIX BIO PRIVATE LIMITED (IN) | 2024-02-20 | — | — | US | claimed |
| US-11890421-B2 | Methods for potentiating antimicrobial agents | BEYOND AIR LTD (IL) | 2024-02-06 | — | — | US | claimed |
| CN-115926141-A | Preparation method of cation-pi type coating modified carbon fiber and carbon fiber composite material | 长春工业大学 | 2023-04-07 | — | — | CN | claimed |
| EP-4087536-A1 | STABLE CYCLODEXTRIN FREE CARFILZOMIB FORMULATION | Amgen, Inc. (US) | 2022-11-16 | — | — | EP | claimed |
| CN-1196676-A | Ophthalmic compositions containing cyclodextrins and quaternary ammonium compounds | NOVARTIS AG (CH) | 1998-10-21 | — | — | CN | claimed |
| WO-1998041208-A1 | COMPOSITIONS AND METHODS FOR REDUCING OCULAR HYPERTENSION | NOVARTIS AG (CH) | 1998-09-24 | — | — | WO | claimed |
| EP-0862414-A1 | OPHTHALMIC COMPOSITIONS CONTAINING CYCLODEXTRINS AND QUATERNARY AMMONIUM COMPOUNDS | Novartis AG (CH) | 1998-09-09 | — | — | EP | claimed |
| EP-0841566-A1 | Positive control plasma for lupus anticoagulant | Pentapharm A.G. (CH) | 1998-05-13 | — | — | EP | claimed |
| WO-1997042941-A2 | BUCCAL DELIVERY SYSTEM | NOVARTIS CONSUMER HEALTH S.A. (CH) | 1997-11-20 | — | — | WO | claimed |
| WO-1997010805-A1 | OPHTHALMIC COMPOSITIONS CONTAINING CYCLODEXTRINS AND QUATERNARY AMMONIUM COMPOUNDS | NOVARTIS AG (CH) | 1997-03-27 | — | — | WO | claimed |
| EP-0420798-B1 | Antimicrobial compositions | CIBA VISION AG (CH) | 1994-03-23 | — | — | EP | claimed |
| EP-0420798-A1 | Antimicrobial compositions | Ciba Vision AG, Hettlingen (CH) | 1991-04-03 | — | — | EP | claimed |
| US-4764527-A | Hydroxypyrazole derivatives, composition containing them and their use against microorganisms | BASF AKTIENGESELLSCHAFT (DE) | 1988-08-16 | — | — | US | claimed |
| US-4588583-A | ACRYLATES, ESTERS, BONE CEMENT | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-05-13 | — | — | US | claimed |