Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | LGMN | Q99538 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2255261 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TSHRHSD11B1SSTR5GRK2 | |
| SCHEMBL3155412 | 0.84 | KMT2A (0.56) | ALDH1A1HSD11B1SSTR5GRK2KMT2A | |
| SCHEMBL2250089 | 0.84 | KMT2A (0.56) | ALDH1A1HSD11B1SSTR5GRK2KMT2A | |
| SCHEMBL2250087 | 0.84 | KMT2A (0.56) | ALDH1A1HSD11B1SSTR5GRK2KMT2A | |
| SCHEMBL3032058 | 0.83 | HSD11B1 (0.49) | ALDH1A1HSD11B1SSTR5KMT2ATDP1 | |
| SCHEMBL3037653 | 0.83 | HSD11B1 (0.49) | ALDH1A1HSD11B1SSTR5KMT2ATDP1 | |
| SCHEMBL13045544 | 0.82 | HSD11B1 (0.51) | ALDH1A1HSD11B1SSTR5KMT2ANPC1 | |
| SCHEMBL3021457 | 0.82 | HSD11B1 (0.51) | ALDH1A1HSD11B1SSTR5KMT2ANPC1 | |
| SCHEMBL2998466 | 0.82 | HSD11B1 (0.51) | ALDH1A1HSD11B1SSTR5KMT2ANPC1 | |
| SCHEMBL3155229 | 0.80 | SSTR5 (0.46) | HSD11B1SSTR5GRK2KMT2ACTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999115-B2 | Spiro antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (SE) | 2011-08-16 | — | — | US | disclosed |
| EP-2066678-B1 | SPIRO ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-02-10 | — | — | EP | disclosed |
| US-20090270375-A1 | SPIRO ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270375-A1 | SPIRO ANTIBIOTIC DERIVATIVES | NR0B1, NRDC, NR4A1 | ALDH1A1 573/4885TSHR 508/4885HSD11B1 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.