Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155227 | 1.00 | SSTR5 (0.46) | SSTR5KMT2AGRK2CTDSP1HSD11B1 | |
| SCHEMBL3155412 | 0.84 | KMT2A (0.56) | SSTR5KMT2AGRK2CTDSP1HSD11B1 | |
| SCHEMBL2250089 | 0.84 | KMT2A (0.56) | SSTR5KMT2AGRK2CTDSP1HSD11B1 | |
| SCHEMBL2250087 | 0.84 | KMT2A (0.56) | SSTR5KMT2AGRK2CTDSP1HSD11B1 | |
| SCHEMBL2254545 | 0.82 | SSTR5 (0.44) | SSTR5KMT2AGRK2CTDSP1POLB | |
| SCHEMBL3150858 | 0.81 | SSTR5 (0.46) | SSTR5KMT2AGRK2CTDSP1POLB | |
| SCHEMBL3139938 | 0.81 | SSTR5 (0.46) | SSTR5KMT2AGRK2CTDSP1POLB | |
| SCHEMBL2255259 | 0.80 | ALDH1A1 (0.47) | SSTR5KMT2AGRK2CTDSP1HSD11B1 | |
| SCHEMBL2255261 | 0.80 | ALDH1A1 (0.47) | SSTR5KMT2AGRK2CTDSP1HSD11B1 | |
| SCHEMBL3737534 | 0.80 | NPY5R (0.48) | SSTR5HSD11B1ADRA1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066678-B1 | SPIRO ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-02-10 | — | — | EP | disclosed |
| EP-2066678-A1 | SPIRO ANTIBIOTIC DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008026172-A1 | SPIRO ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-06 | — | — | WO | disclosed |