Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173326 | 0.85 | ACACB (0.50) | GRM5GRM4ALDH1A1GABRG2GABRB3 | |
| SCHEMBL19385078 | 0.83 | GRM5 (0.52) | GRM5CLK4EGLN1ALDH1A1USP30 | |
| SCHEMBL30800091 | 0.82 | ALDH1A1 (0.54) | ALDH1A1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29735406 | 0.81 | ALDH1A1 (0.51) | ALDH1A1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3712306 | 0.81 | ALDH1A1 (0.51) | ALDH1A1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL22556954 | 0.80 | KDM4C (0.55) | GRM5CLK4ALDH1A1GABRG2GABRB3 | |
| SCHEMBL7822720 | 0.80 | PLAU (0.61) | XDHSLC22A12GABRG2GABRB3GABRA5 | |
| SCHEMBL23201168 | 0.80 | ALDH1A1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13188268 | 0.79 | EGFR (0.51) | ALDH1A1 | |
| SCHEMBL22557560 | 0.79 | KMO (0.49) | GRM5CLK4EGLN1DYRK1APLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020212351-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |
| WO-2020212351-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |