Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Imidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL145932 | 0.98 | — | — | |
| Imidazole SCHEMBL29411697 | 0.98 | ALDH1A1 (0.65) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL28966030 | 0.98 | ALDH1A1 (0.65) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL30320112 | 0.98 | ALDH1A1 (0.65) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL3639063 | 0.95 | ALDH1A1 (0.62) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL29365438 | 0.95 | ALDH1A1 (0.62) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL29188028 | 0.95 | ALDH1A1 (0.62) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL28796723 | 0.95 | ALDH1A1 (0.62) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL27735299 | 0.95 | ALDH1A1 (0.62) | ALDH1A1FKBP5FFAR3LCKFYN | |
| Imidazole SCHEMBL28213689 | 0.95 | ALDH1A1 (0.62) | ALDH1A1FKBP5FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574113-A | Zoledronic acid intermediate compound | 鲁南制药集团股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-102553645-B | Ionic liquid 2-(1-imidazolyl)-supported acetate catalyst and preparation method thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2013-10-09 | — | — | CN | disclosed |
| CN-102775444-A | New preparation method of zoledronic acid | HENGSHUI KANGYI MEDICAL TECHNOLOGY DEV CO LTD | 2012-11-14 | — | — | CN | disclosed |
| CN-102553645-A | Ionic liquid 2-(1-imidazolyl)-supported acetate catalyst and preparation method thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2012-07-11 | — | — | CN | disclosed |
| US-20110206617-A1 | MODIFIED POLYSACCHARIDES FOR DRUG AND CONTRAST AGENT DELIVERY | WILLIAM MARSH RICE UNIVERSITY | 2011-08-25 | — | — | US | disclosed |
| CN-101223143-A | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |
| CN-1693308-A | Process for preparing dazoline phospho acid | YANGZIJIANG PHARMACEUTICAL GRO (CN) | 2005-11-09 | — | — | CN | disclosed |
| CN-1472215-A | Synthesis of product prepared from imidazole acted with halogenated acetate ethyl ester | 武汉麦林新技术开发有限公司 | 2004-02-04 | — | — | CN | disclosed |
| EP-0618913-B1 | IMIDAZOLYL OR IMIDAZOYLALKYL SUBSTITUTED WITH A FOUR OR FIVE MEMBERED NITROGEN CONTAINING HETEROCYCLIC RING | SCHERING CORP (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5463074-A | Treating allergy, inflammation, hypertension, glaucoma, central nervous system disorders | SCHERING CORPORATION (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0533242-A2 | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists | MERCK & CO. INC. (US) | 1993-03-24 | — | — | EP | disclosed |