Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712029 | 0.84 | NPC1 (0.47) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| SCHEMBL23709229 | 0.84 | CES2 (0.55) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL23294373 | 0.83 | MEN1 (0.50) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| SCHEMBL2538090 | 0.82 | TSHR (0.58) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| SCHEMBL22570695 | 0.82 | KCNQ3 (0.43) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL29391461 | 0.81 | KMO (0.44) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| SCHEMBL14982171 | 0.81 | PIM1 (0.52) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL27503767 | 0.80 | KCNQ3 (0.44) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| SCHEMBL7144096 | 0.80 | GSK3B (0.59) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR | |
| SCHEMBL1924889 | 0.80 | PLOD2 (0.60) | TAS1R3TAS1R1TAS1R2SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531503-A1 | GAMMA SECRETASE MODULATERS | F. Hoffmann-La Roche AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011092272-A1 | GAMMA SECRETASE MODULATERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-04 | — | — | WO | disclosed |
| US-20110190269-A1 | GAMMA SECRETASE MODULATORS | HOFFMANN-LA ROCHE, INC. | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190269-A1 | GAMMA SECRETASE MODULATORS | BACE1, APH1A, APH1B | TAS1R3 3024/4885TAS1R1 2937/4885TAS1R2 3292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.