Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13604205 | 0.70 | SLC9A1 (0.50) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL5694968 | 0.64 | SLC9A1 (0.54) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL19071761 | 0.63 | POLB (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL15040780 | 0.63 | SLC9A1 (0.53) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL14596693 | 0.62 | NPC1 (0.44) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL1259144 | 0.62 | POLB (0.52) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL1829869 | 0.62 | POLB (0.52) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL425007 | 0.62 | KMT2A (0.61) | ALDH1A1KDM4EKMT2AMAPTHTT | |
| SCHEMBL28389006 | 0.62 | POLB (0.47) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL19619922 | 0.61 | SLC9A1 (0.50) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191467-B1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2020-10-21 | — | — | EP | disclosed |