SCHEMBL22562598

SCHEMBL22562598

N#Cc1ccc(-c2ccc3c(c2)c2cc(-c4ccc(C#N)cc4)ccc2n3-c2cc(-c3cccc(-c4ccccc4)n3)c(C(F)(F)F)cc2-n2c3ccc(-c4ccc(C#N)cc4)cc3c3cc(-c4ccc(C#N)cc4)ccc32)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.42
PDK2 Q15119 2/20 0.39
MYC P01106 1/20 0.38
ALDH1A3 P47895 2/20 0.38
GABRA1 P14867 1/20 0.37
GABRG2 P18507 1/20 0.37
GABRB3 P28472 1/20 0.37
GABRA5 P31644 1/20 0.37
GABRA3 P34903 1/20 0.37
HSD11B1 P28845 2/20 0.37
SYK P43405 1/20 0.37
SCN9A Q15858 3/20 0.36
CYP11B2 P19099 1/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
ABCB1 P08183 1/20 0.36
ABCG2 Q9UNQ0 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562316 0.97 KIF11 (0.40) KIF11PDK2MYCALDH1A3GABRA1
SCHEMBL22562416 0.93 ACP1 (0.39) PDK2ALDH1A3HSD11B1SYKSCN9A
SCHEMBL22562315 0.92 ALDH1A3 (0.40) KIF11PDK2ALDH1A3GABRA1GABRG2
SCHEMBL22562311 0.92 KIF11 (0.42) KIF11PDK2MYCALDH1A3GABRA1
SCHEMBL22562617 0.92 ALDH1A3 (0.35) KIF11PDK2MYCALDH1A3GABRA1
SCHEMBL22562312 0.91 KIF11 (0.40) KIF11PDK2MYCALDH1A3GABRA1
SCHEMBL22562409 0.90 ACP1 (0.39) PDK2ALDH1A3HSD11B1SYKSCN9A
SCHEMBL22562292 0.90 CYP11B2 (0.39) CYP11B2
SCHEMBL22562487 0.90 SCN9A (0.36) PDK2GABRA1GABRG2GABRB3GABRA5
SCHEMBL21546753 0.89 ALDH1A3 (0.40) PDK2ALDH1A3GABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed