Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19502797 | 0.84 | KDM1A (0.43) | KDM4ETACR1JAK1JAK2ITGB3 | |
| SCHEMBL25840967 | 0.79 | KDM4E (0.40) | KDM4ETACR1JAK1JAK2ITGB3 | |
| SCHEMBL19502796 | 0.77 | KDM4E (0.36) | KDM4ETACR1JAK1JAK2ITGB3 | |
| SCHEMBL4630504 | 0.74 | ATM (0.50) | KDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL11948185 | 0.74 | ATM (0.44) | KDM4EITGB3ITGA2BALDH1A1NPC1 | |
| SCHEMBL17176221 | 0.74 | KDM4E (0.39) | KDM4ETACR1JAK1JAK2NAMPT | |
| SCHEMBL25481307 | 0.73 | TACR1 (0.35) | KDM4ETACR1JAK1JAK2KDM1A | |
| SCHEMBL13383616 | 0.73 | GNAI3 (0.49) | KDM4EITGB3ITGA2BCYP3A4OPRM1 | |
| SCHEMBL791911 | 0.72 | KMT2A (0.48) | KDM4EALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7466514 | 0.72 | KMT2A (0.48) | KDM4EALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464273-B9 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-10-21 | — | — | EP | disclosed |