Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25840967 | 0.90 | KDM4E (0.40) | KDM4EPIK3R1PIK3CAALDH1A1TACR1 | |
| SCHEMBL25810460 | 0.88 | ALDH1A1 (0.42) | KDM4EPIK3R1PIK3CAALDH1A1RORC | |
| SCHEMBL17173025 | 0.81 | KDM4E (0.35) | KDM4EPIK3R1PIK3CAALDH1A1OPRM1 | |
| SCHEMBL17173026 | 0.81 | KDM4E (0.35) | KDM4EPIK3R1PIK3CAALDH1A1OPRM1 | |
| SCHEMBL19502797 | 0.79 | KDM1A (0.43) | KDM4EPIK3R1PIK3CAALDH1A1OPRM1 | |
| SCHEMBL16621834 | 0.78 | ALDH1A1 (0.55) | PIK3R1PIK3CAALDH1A1SPROPRM1 | |
| SCHEMBL19502796 | 0.77 | KDM4E (0.36) | KDM4EPIK3R1PIK3CAOPRM1TACR1 | |
| SCHEMBL25931529 | 0.76 | CYP1A2 (0.44) | OPRM1OPRL1NAMPT | |
| SCHEMBL18460887 | 0.76 | SPR (0.37) | ALDH1A1SPROPRM1OPRL1NAMPT | |
| SCHEMBL11892690 | 0.74 | OPRM1 (0.47) | ALDH1A1SPROPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260439-B2 | Dihydropyrrolopyrimidine derivatives | PFIZER INC. (US) | 2016-02-16 | — | — | US | disclosed |
| WO-2015155624-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | PFIZER INC. (US) | 2015-10-15 | — | — | WO | disclosed |
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | PFIZER (US) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | DPYD, TPD52L2, DTYMK | KDM4E 512/4885PIK3R1 2181/4885PIK3CA 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.