Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17176221 | 0.90 | KDM4E (0.39) | KDM4ETACR1HSP90AA1HSP90AB1NAMPT | |
| SCHEMBL19502797 | 0.85 | KDM1A (0.43) | KDM4ETACR1NAMPTALDH1A1JAK1 | |
| SCHEMBL19502796 | 0.82 | KDM4E (0.36) | KDM4ETACR1HSP90AA1HSP90AB1NAMPT | |
| SCHEMBL25810460 | 0.81 | ALDH1A1 (0.42) | KDM4EALDH1A1PIK3R1PIK3CA | |
| SCHEMBL22562867 | 0.79 | KDM4E (0.37) | KDM4ETACR1NAMPTALDH1A1JAK1 | |
| SCHEMBL11948185 | 0.79 | ATM (0.44) | KDM4EALDH1A1NPC1ITGB3ITGA2B | |
| SCHEMBL4630504 | 0.79 | ATM (0.50) | KDM4EALDH1A1KMT2AMEN1GAA | |
| SCHEMBL14417828 | 0.77 | NAMPT (0.42) | KDM4ENAMPTALDH1A1EPHX2JAK1 | |
| SCHEMBL13360768 | 0.77 | ALDH1A1 (0.52) | NAMPTALDH1A1EPHX2KMT2AMEN1 | |
| SCHEMBL791911 | 0.77 | KMT2A (0.48) | KDM4EALDH1A1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116763-A1 | PYRIDAZINE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海优理惠生医药有限公司 | 2023-06-29 | — | — | WO | disclosed |