Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.71 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573609 | 0.85 | ADORA2A (0.66) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL22573768 | 0.84 | ADORA2A (0.65) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL22573740 | 0.83 | ADORA2A (0.67) | ADORA2AADORA1ADORA3ADORA2BSMN1; SMN2 | |
| SCHEMBL22573807 | 0.83 | ADORA2A (1.00) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL22574015 | 0.83 | ADORA3 (0.63) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL22573508 | 0.82 | KMT2A (0.57) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL22573552 | 0.81 | ADORA2A (0.66) | ADORA2AADORA1ADORA3ADORA2BHSD17B10 | |
| SCHEMBL22573747 | 0.81 | L3MBTL1 (0.56) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL22573340 | 0.81 | L3MBTL1 (0.53) | ADORA2AADORA1ADORA3ADORA2BKMT2A | |
| SCHEMBL22573408 | 0.81 | ADORA3 (0.60) | ADORA2AADORA1ADORA3ADORA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |