Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573340 | 0.92 | L3MBTL1 (0.53) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL22573734 | 0.91 | KMT2A (0.52) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL22573747 | 0.87 | L3MBTL1 (0.56) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL22573595 | 0.84 | MAPT (0.58) | KMT2AALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL22573404 | 0.82 | ADORA2A (0.71) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL22573798 | 0.79 | ALDH1A1 (0.61) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL22573967 | 0.79 | ATR (0.66) | ALDH1A1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL22573719 | 0.79 | LMNA (0.62) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL22573371 | 0.79 | MAPT (0.58) | KMT2AALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL22573541 | 0.76 | ALDH1A1 (0.61) | KMT2AL3MBTL1ALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |