Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | XBP1 | P17861 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573723 | 0.85 | RAB9A (0.59) | KDM4EALDH1A1TSHRHPGDMAPT | |
| SCHEMBL22574062 | 0.84 | GRM5 (0.54) | KDM4EMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22573696 | 0.83 | ATM (0.56) | ALDH1A1HPGDMEN1KMT2ARAB9A | |
| SCHEMBL22573629 | 0.82 | GRM5 (0.63) | ALDH1A1HPGDHSD17B10KMT2ARAB9A | |
| SCHEMBL22573756 | 0.82 | NPC1 (0.56) | KDM4EALDH1A1TSHRHPGDMAPT | |
| SCHEMBL22573853 | 0.82 | ALDH1A1 (0.53) | KDM4EALDH1A1TSHRHPGDMAPT | |
| SCHEMBL22573737 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1TSHRHPGDMAPT | |
| SCHEMBL22573343 | 0.80 | TSHR (0.58) | KDM4EALDH1A1TSHRHPGDMAPT | |
| SCHEMBL22573273 | 0.80 | HPGDS (0.47) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL22573837 | 0.80 | ATR (0.51) | KDM4EALDH1A1HPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |