Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252902 | 0.94 | ALDH1A1 (0.54) | PLA2G2AALDH1A1NPSR1SMN1; SMN2MAPT | |
| SCHEMBL2254318 | 0.81 | ERAP1 (0.51) | ALDH1A1NPSR1CYP2D6SMN1; SMN2MAPT | |
| SCHEMBL3897557 | 0.80 | SMN1; SMN2 (0.48) | CYP1A2SMN1; SMN2HIF1AHDAC6MMP2 | |
| SCHEMBL2253214 | 0.78 | MAPT (0.57) | ALDH1A1NPSR1SMN1; SMN2HIF1AMAPT | |
| SCHEMBL2492282 | 0.75 | CYP2D6 (0.59) | KDM4ECYP1A2CYP2D6PDE4ASMN1; SMN2 | |
| SCHEMBL2257130 | 0.74 | DAO (0.49) | ALDH1A1KDM4ESMN1; SMN2MAPTHTT | |
| SCHEMBL2255065 | 0.72 | DAO (0.48) | ALDH1A1NPSR1POLB | |
| SCHEMBL2257545 | 0.72 | MEN1 (0.44) | ALDH1A1NPSR1MAPTPOLBKMT2A | |
| SCHEMBL2253443 | 0.72 | DAO (0.41) | ALDH1A1NPSR1KMT2A | |
| SCHEMBL14135832 | 0.71 | SLC5A1 (0.51) | PLA2G2AALDH1A1KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989424-B2 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2011-08-02 | — | — | US | disclosed |
| EP-1354888-B1 | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES | KISSEI PHARMACEUTICAL (JP) | 2009-05-20 | — | — | EP | disclosed |
| US-20090093419-A1 | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES | KISSEI PHARMACEUTICAL CO. LTD. (JP) | 2009-04-09 | — | — | US | disclosed |
| US-7465713-B2 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-12-16 | — | — | US | disclosed |
| US-7429568-B2 | Antidiabetic agents; human SGLT2 (sodium ion / glucose cotransporter 2) inhibitors; hyperglycemia, obesity; 3-(6-O-ethoxycarbonyl- beta -D-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-1-isopropyl-5-methylpyrazole | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| US-7393838-B2 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-07-01 | — | — | US | disclosed |
| US-7115575-B2 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-10-03 | — | — | US | disclosed |
| US-7084123-B2 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-08-01 | — | — | US | disclosed |
| US-7056892-B2 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-06-06 | — | — | US | disclosed |
| US-20060094667-A1 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | KISSEI PHARMACEUTICAL CO., LTD. | 2006-05-04 | — | — | US | disclosed |
| US-20060025352-A1 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | Kissei Pharmaceutical Co.,Ltd. | 2006-02-02 | — | — | US | disclosed |
| US-6972283-B2 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-12-06 | — | — | US | disclosed |
| US-20050261205-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. | 2005-11-24 | — | — | US | disclosed |
| US-20050261206-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. | 2005-11-24 | — | — | US | disclosed |
| US-20050137143-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. | 2005-06-23 | — | — | US | disclosed |
| US-20040147729-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. | 2004-07-29 | — | — | US | disclosed |
| EP-1213296-B1 | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES IN THE PRODUCTION THEREOF | KISSEI PHARMACEUTICAL (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-20040063646-A1 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1354888-A1 | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES | Kissei Pharmaceutical Co., Ltd. (JP) | 2003-10-22 | — | — | EP | disclosed |
| EP-1213296-A1 | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2002-06-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261205-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | SLC5A1, SLC5A2, UGGT1 | PLA2G2A 3392/4885ALDH1A1 288/4885NPSR1 2584/4885 |
| US-20090093419-A1 | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES | SLC5A2, SLC5A1, SLC2A4 | PLA2G2A 3958/4885ALDH1A1 1040/4885NPSR1 1689/4885 |
| US-20060094667-A1 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | SLC5A2, SLC5A1, SLC2A2 | PLA2G2A 3991/4885ALDH1A1 1026/4885NPSR1 1705/4885 |
| US-20040063646-A1 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | SLC5A2, SLC5A1, UGGT1 | PLA2G2A 3894/4885ALDH1A1 1121/4885NPSR1 2090/4885 |
| US-20060025352-A1 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines | SLC5A2, SLC5A1, SLC2A2 | PLA2G2A 3991/4885ALDH1A1 1026/4885NPSR1 1705/4885 |
| US-20050137143-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | SLC5A1, SLC5A2, UGGT1 | PLA2G2A 3392/4885ALDH1A1 288/4885NPSR1 2584/4885 |
| US-20040147729-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | SLC5A1, SLC5A2, UGGT1 | PLA2G2A 4107/4885ALDH1A1 352/4885NPSR1 2893/4885 |
| US-20050261206-A1 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof | SLC5A1, SLC5A2, UGGT1 | PLA2G2A 3392/4885ALDH1A1 288/4885NPSR1 2584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.