Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440978 | 0.92 | L3MBTL1 (0.69) | CYP2D6CYP1A2LTA4HL3MBTL1CYP2C9 | |
| SCHEMBL2495606 | 0.91 | LMNA (0.62) | CYP2D6CYP1A2KDM4EPDE4ASMN1; SMN2 | |
| SCHEMBL10708237 | 0.88 | CYP1A2 (0.50) | CYP2D6CYP1A2KDM4EPDE4ASMN1; SMN2 | |
| SCHEMBL570564 | 0.88 | L3MBTL1 (0.70) | CYP2D6CYP1A2LTA4HL3MBTL1NR5A1 | |
| SCHEMBL26850 | 0.87 | LTA4H (0.70) | CYP2D6CYP1A2SMN1; SMN2LTA4HNR5A1 | |
| SCHEMBL18995912 | 0.87 | ALDH1A1 (0.65) | KDM4ESMN1; SMN2HIF1ALTA4HNR5A1 | |
| SCHEMBL18995913 | 0.87 | L3MBTL1 (0.68) | CYP2D6CYP1A2LTA4HL3MBTL1NR5A1 | |
| SCHEMBL18854865 | 0.87 | L3MBTL1 (0.68) | CYP2D6CYP1A2LTA4HL3MBTL1NR5A1 | |
| SCHEMBL14618159 | 0.87 | NR5A1 (0.58) | LTA4HL3MBTL1NR5A1TSHR | |
| SCHEMBL28676091 | 0.87 | L3MBTL1 (0.68) | CYP2D6CYP1A2LTA4HL3MBTL1NR5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380567-B1 | MELANIN PRODUCTION INHIBITOR | POLA CHEM IND INC (JP) | 2019-01-16 | — | — | EP | disclosed |
| US-9567501-B2 | Silicone pressure-sensitive adhesive composition having improved substrate adhesion and pressure-sensitive adhesive article | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2017-02-14 | — | — | US | disclosed |
| EP-3009123-A1 | MELANIN PRODUCTION INHIBITOR | Pola Chemical Industries Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20150328107-A1 | MELANIN PRODUCTION INHIBITOR | POLA CHEMICAL INDUSTRIES INC. (JP) | 2015-11-19 | — | — | US | disclosed |
| US-20150240141-A1 | SILICONE PRESSURE-SENSITIVE ADHESIVE COMPOSITION HAVING IMPROVED SUBSTRATE ADHESION AND PRESSURE-SENSITIVE ADHESIVE ARTICLE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2015-08-27 | — | — | US | disclosed |
| EP-2845587-A2 | Melanin production inhibitor | Pola Chemical Industries Inc. (JP) | 2015-03-11 | — | — | EP | disclosed |
| US-20140363389-A1 | MELANIN PRODUCTION INHIBITOR | POLA CHEMICAL INDUSTRIES INC. (JP) | 2014-12-11 | — | — | US | disclosed |
| US-8846012-B2 | Melanin production inhibitor | POLA CHEMICAL INDUSTRIES INC. (JP) | 2014-09-30 | — | — | US | disclosed |
| EP-2380567-A1 | MELANIN PRODUCTION INHIBITOR | Pola Chemical Industries Inc. (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-20110243865-A1 | MELANIN PRODUCTION INHIBITOR | POLA CHEMICAL INDUSTRIES INC. (JP) | 2011-10-06 | — | — | US | disclosed |
| EP-1754597-B1 | Lithographic printing plate precursor and lithographic printing process | FUJIFILM CORP (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-20100144872-A1 | New Methylenebisphenyl Compounds Useful in the Treatment of Inflammation | BIOLIPOX AB | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110243865-A1 | MELANIN PRODUCTION INHIBITOR | TYR, F12, TH | CYP2D6 141/4885CYP1A2 28/4885KDM4E 2772/4885 |
| US-20150328107-A1 | MELANIN PRODUCTION INHIBITOR | TYR, MC1R, F12 | CYP2D6 116/4885CYP1A2 28/4885KDM4E 3096/4885 |
| US-20140363389-A1 | MELANIN PRODUCTION INHIBITOR | TYR, F12, MC1R | CYP2D6 137/4885CYP1A2 27/4885KDM4E 3125/4885 |
| US-20100144872-A1 | New Methylenebisphenyl Compounds Useful in the Treatment of Inflammation | LTC4S, LTB4R2, LTB4R | CYP2D6 278/4885CYP1A2 146/4885KDM4E 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.